Products 865311-47-3
CAS 865311-47-3 appears in our catalog under these names: Quarfloxin/ 99.18% (existing batch purity), Quarfloxin, Quarfloxin 95%, 5-Fluoro-N-(2-((S)-1-methylpyrrolidin-2-yl)ethyl)-3-oxo-6-(3-(pyrazin-2-yl)pyrrolidin-1-yl)-3H-benzo[b]pyrido[3,2,1-kl]phenoxazine-2-carboxamide, Quarfloxin, 99.88%. Offered by: TargetMol, Biosynth, Ambeed, Chemat, MedChemExpress. Available pack sizes: 1mg, 5mg, 10mg, 25mg, 50mg, 100mg, 100 mg, 50 mg.
Itarnafloxin is an organic heteropentacyclic compound that is 3H-benzo[b]pyrido[3,2,1-kl]phenoxazin-3-one substituted by 2-[(2S)-1-methylpyrrolidin-2-yl]ethanaminoacyl, fluoro, and 3-(pyrazin-2-yl)pyrrolidin-1-yl groups at positions 2, 5 and 6, respectively. It is a G-quadruplex interactive agent, previously in clinical trials for the treatment of carcinoid/neuroendocrine tumours (now discontinued). It has a role as a topoisomerase II inhibitor, an antineoplastic agent, an antimalarial and an apoptosis inducer. It is a secondary carboxamide, a phenoxazine, an organofluorine compound, an organic heteropentacyclic compound, a member of pyrazines and a N-alkylpyrrolidine.
Source: ChEBI
| Molecular formula | C35H33FN6O3 |
|---|---|
| Molecular weight | 604.7 g/mol |
| IUPAC name | 15-fluoro-N-[2-[(2S)-1-methylpyrrolidin-2-yl]ethyl]-18-oxo-14-(3-pyrazin-2-ylpyrrolidin-1-yl)-12-oxa-1-azapentacyclo[11.7.1.02,11.04,9.017,21]henicosa-2,4,6,8,10,13(21),14,16,19-nonaene-19-carboxamide |
| InChIKey | WOQIDNWTQOYDLF-CGAIIQECSA-N |
| SMILES | CN1CCC[C@H]1CCNC(=O)C2=CN3C4=CC5=CC=CC=C5C=C4OC6=C3C(=CC(=C6N7CCC(C7)C8=NC=CN=C8)F)C2=O |
Computed by PubChem (NCBI)