Products 927880-90-8
CAS 927880-90-8 appears in our catalog under these names: RAF 265, RAF265/ 99.18% (existing batch purity), RAF265, RAF265 99%, 1-Methyl-5-((2-(5-(trifluoromethyl)-1H-imidazol-2-yl)pyridin-4-yl)oxy)-N-(4-(trifluoromethyl)phenyl)-1H-benzo[d]imidazol-2-amine, 99%, 99%. Offered by: TRC, TargetMol, GLPBio, Biosynth, Ambeed. Available pack sizes: 100mg, 1mg, 2mg, 5mg, 10mg, 25mg, 50mg, 10mM (in 1ml dmso).
CHIR-265 is a member of the class of benzimidazoles that is 1H-benzimidazole substituted by methyl, [4-(trifluoromethyl)phenyl]amino, and {2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl}oxy groups at positions 1, 2, and 5, respectively. It is an inhibitor of RAF kinases, including the BRAF V600E mutant. It has a role as an antiviral agent, an antineoplastic agent, an angiogenesis inhibitor, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor, an apoptosis inducer and a B-Raf inhibitor. It is a member of benzimidazoles, a member of imidazoles, a member of pyridines, an aromatic ether, an organofluorine compound, a substituted aniline and a member of (trifluoromethyl)benzenes.
Source: ChEBI
| Molecular formula | C24H16F6N6O |
|---|---|
| Molecular weight | 518.4 g/mol |
| IUPAC name | 1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine |
| InChIKey | YABJJWZLRMPFSI-UHFFFAOYSA-N |
| SMILES | CN1C2=C(C=C(C=C2)OC3=CC(=NC=C3)C4=NC=C(N4)C(F)(F)F)N=C1NC5=CC=C(C=C5)C(F)(F)F |
Computed by PubChem (NCBI)