Repotrectinib

cas: 1802220-02-5 — see every product listed under this CAS number, including other names

Repotrectinib (CAS 1802220-02-5) is a chemical reagent available from Chemat. Available pack sizes: 5mg, 10mg, 25mg, 50mg, 2mg. Offered by: GLPBio, Biosynth.

brandGLPBio
catalog numberGC19362-5
cas1802220-02-5
size5mg
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Available pack sizes

brand size price
GLPBio 5mg 751.50 Pln
GLPBio 10mg 919.99 Pln
GLPBio 25mg 1425.49 Pln
GLPBio 50mg 1930.98 Pln
Biosynth 5mg price on request
Biosynth 2mg price on request
Biosynth 10mg price on request
Biosynth 25mg price on request

properties

purityNo data
delivery timeTo be confirmed by Chemat
Structural formula: {0} (CAS {1})

Repotrectinib is an azamacrocycle with formula C18H18FN5O2. It is a tyrosine kinase inhibitor (highly potent against ROS1, TRKA-C, and ALK) used for the treatment of locally advanced or metastatic ROS1-positive non-small cell lung cancer. It has a role as an antineoplastic agent and an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor. It is a secondary carboxamide, a cyclic ether, a pyrazolopyrimidine, an azamacrocycle and a member of monofluorobenzenes.

Source: ChEBI

Identity
Molecular formulaC18H18FN5O2
Molecular weight355.4 g/mol
IUPAC name(3R,11S)-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentazatetracyclo[13.5.2.04,9.018,22]docosa-1(21),4(9),5,7,15(22),16,19-heptaen-14-one
InChIKeyFIKPXCOQUIZNHB-WDEREUQCSA-N
SMILESC[C@H]1CNC(=O)C2=C3N=C(C=CN3N=C2)N[C@@H](C4=C(O1)C=CC(=C4)F)C

Computed by PubChem (NCBI)

Synonyms: Repotrectinib, Augtyro, repotrectinibum, Multikinase Inhibitor TPX-0005, Multi-kinase Inhibitor TPX-0005, ALK/ROS1/NTRK/SRC/FAK Multikinase Inhibitor TPX-0005, Ropotrectinib, Repotrectinib [USAN], Repotrectinib(TPX-005), Repotrectinib (TPX-0005)
Isomers (same molecular formula)
ethyl 4-[(E)-2-(dimethylamino)ethenyl]-8-(4-fluorophenyl)pyrazolo[5,1-c][1,2,4]triazine-3-carboxylate C18H18FN5O2
N-[2-(4-ethyl-6-oxo-1H-pyrimidin-2-yl)-5-methylpyrazol-3-yl]-2-fluoro-5-methylbenzamide C18H18FN5O2

Also listed as

Repotrectinib/ 99.86% (existing batch purity) TargetMol CAS 1802220-02-5
Repotrectinib, 99.95% MedChemExpress CAS 1802220-02-5
Repotrectinib, 99% Ambeed CAS 1802220-02-5
(7S,13R)-11-Fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-1,15-etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one, 99% BLDpharm CAS 1802220-02-5
1,15-Etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one,11-fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-, (7S,13R)-, 99% Chemat CAS 1802220-02-5