Products 1802220-02-5

CAS 1802220-02-5 appears in our catalog under these names: Repotrectinib, Repotrectinib/ 99.86% (existing batch purity), Repotrectinib 99%, 1,15-Etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one,11-fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-, (7S,13R)-, 99%, 99%, Repotrectinib, 99.95%. Offered by: GLPBio, TargetMol, Biosynth, Ambeed, Chemat. Available pack sizes: 5mg, 1mg, 2mg, 10mg, 25mg, 50mg, 100mg, 250mg.

Repotrectinib
GLPBio, Biosynth
  • size: 5mg, 10mg, 25mg, 50mg
  • Variants: 8
from 751.50
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Repotrectinib/ 99.86% (existing batch purity)
TargetMol
  • size: 1mg, 2mg, 5mg, 10mg
  • Variants: 7
from 478.94
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Repotrectinib 99%
Ambeed
  • size: 1mg, 5mg, 25mg, 100mg
  • Variants: 7
from 120.06
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1,15-Etheno-1H-pyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one,11-fluoro-6,7,13,14-tetrahydro-7,13-dimethyl-, (7S,13R)-, 99%, 99%
Chemat
  • size: 5mg, 10mg, 50mg, 100mg
  • Variants: 7
from 117.20
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Repotrectinib, 99.95%
MedChemExpress
  • size: 100 mg, 50 mg, 25 mg, 5 mg
  • Variants: 6
from 649.42
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Structural formula: {0} (CAS {1})

Repotrectinib is an azamacrocycle with formula C18H18FN5O2. It is a tyrosine kinase inhibitor (highly potent against ROS1, TRKA-C, and ALK) used for the treatment of locally advanced or metastatic ROS1-positive non-small cell lung cancer. It has a role as an antineoplastic agent and an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor. It is a secondary carboxamide, a cyclic ether, a pyrazolopyrimidine, an azamacrocycle and a member of monofluorobenzenes.

Source: ChEBI

Identity
Molecular formulaC18H18FN5O2
Molecular weight355.4 g/mol
IUPAC name(3R,11S)-6-fluoro-3,11-dimethyl-10-oxa-2,13,17,18,21-pentazatetracyclo[13.5.2.04,9.018,22]docosa-1(21),4(9),5,7,15(22),16,19-heptaen-14-one
InChIKeyFIKPXCOQUIZNHB-WDEREUQCSA-N
SMILESC[C@H]1CNC(=O)C2=C3N=C(C=CN3N=C2)N[C@@H](C4=C(O1)C=CC(=C4)F)C

Computed by PubChem (NCBI)

Synonyms: Repotrectinib, Augtyro, repotrectinibum, Multikinase Inhibitor TPX-0005, Multi-kinase Inhibitor TPX-0005, ALK/ROS1/NTRK/SRC/FAK Multikinase Inhibitor TPX-0005, Ropotrectinib, Repotrectinib [USAN], Repotrectinib(TPX-005), Repotrectinib (TPX-0005)
Isomers (same molecular formula)
ethyl 4-[(E)-2-(dimethylamino)ethenyl]-8-(4-fluorophenyl)pyrazolo[5,1-c][1,2,4]triazine-3-carboxylate C18H18FN5O2