Rolapitant, 99%

cas: 552292-08-7 — see every product listed under this CAS number, including other names

Rolapitant, 99% (CAS 552292-08-7) is a chemical reagent available from Chemat. Available pack sizes: 10mg, 25mg, 50mg, 100mg, 250mg, 1g. Offered by: Ambeed, Chemat, Fluorochem.

brandAmbeed
catalog numberA190999-10mg
cas552292-08-7
size10mg
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Available pack sizes

brand size price
Ambeed 10mg 592.88 Pln
Ambeed 25mg 998.94 Pln
Ambeed 50mg 1466.19 Pln
Ambeed 100mg 2011.31 Pln
Ambeed 250mg 2984.75 Pln
Ambeed 1g 7362.44 Pln
Chemat 10mg 741.20 Pln
Chemat 25mg 1264.40 Pln
Chemat 50mg 1869.20 Pln
Chemat 100mg 2570.00 Pln
Chemat 250mg 3822.80 Pln
Chemat 1g 9462.80 Pln
Fluorochem 10mg 1372.45 Pln
Fluorochem 25mg 2340.86 Pln
Fluorochem 50mg 3449.84 Pln
Fluorochem 100mg 4761.88 Pln

properties

purity99%
delivery time 2-3 weeks
Structural formula: {0} (CAS {1})

Rolapitant is an azaspiro compound that is 1,7-diazaspiro[4.5]decan-2-one carrying additional phenyl and 1-{[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl substituents at position 8. Used (in the form of the hydrochloride hydrate) for the prevention of delayed nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy. It has a role as an antiemetic and a neurokinin-1 receptor antagonist. It is an ether, a member of piperidines, an azaspiro compound, an organofluorine compound and a member of pyrrolidin-2-ones. It is a conjugate base of a rolapitant(1+).

Source: ChEBI

Identity
Molecular formulaC25H26F6N2O2
Molecular weight500.5 g/mol
IUPAC name(5S,8S)-8-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-8-phenyl-1,9-diazaspiro[4.5]decan-2-one
InChIKeyFIVSJYGQAIEMOC-ZGNKEGEESA-N
SMILESC[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OC[C@]2(CC[C@]3(CCC(=O)N3)CN2)C4=CC=CC=C4

Computed by PubChem (NCBI)

Synonyms: Rolapitant, Varuby, rolapitantum, Sch 619734, Rolapitant free base, Varubi, Rolapitant [INN], Rolapitant [USAN:INN], ROLAPITANT [USAN], Varubi (TN)
Related forms of this compound
(5R,8R)-8-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-8-phenyl-1,9-diazaspiro[4.5]decan-2-one C25H26F6N2O2
(5R,8S)-8-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-8-phenyl-1,9-diazaspiro[4.5]decan-2-one C25H26F6N2O2
(5S,8R)-8-[[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-8-phenyl-1,9-diazaspiro[4.5]decan-2-one C25H26F6N2O2
(5S,8R)-8-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-8-phenyl-1,9-diazaspiro[4.5]decan-2-one C25H26F6N2O2
(5S,8S)-8-[[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-8-phenyl-1,9-diazaspiro[4.5]decan-2-one C25H26F6N2O2
(5R,8R)-8-[[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-8-phenyl-1,9-diazaspiro[4.5]decan-2-one C25H26F6N2O2
(5R,8S)-8-[[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-8-phenyl-1,9-diazaspiro[4.5]decan-2-one C25H26F6N2O2

Also listed as

Rolapitant, 95% Combi-blocks CAS 552292-08-7
Rolapitant Chemat Brand CAS 552292-08-7
Rolapitant/ 98.34% (existing batch purity) TargetMol CAS 552292-08-7
Rolapitant, 99.89% MedChemExpress CAS 552292-08-7
Rolapitant (Standard) MedChemExpress CAS 552292-08-7
(5S,8S)-8-(((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)methyl)-8-phenyl-1,7-diazaspiro[4.5]decan-2-one, 99% BLDpharm CAS 552292-08-7
Rolapitant-d4 Chemat Brand CAS 552292-08-7 (non-labelled)