Products 1799633-27-4

CAS 1799633-27-4 appears in our catalog under these names: S63845/ 98.56% (existing batch purity), S63845, S 63845, S63845 98%, (αR)-α-[[(5S)-5-[3-Chloro-2-methyl-4-[2-(4-methyl-1-piperazinyl)ethoxy]phenyl]-6-(5-fluoro-2-furanyl)thieno[2,3-d]pyrimidin-4-yl]oxy]-2-[[1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl]methoxy]benzenepropanoic acid, 98%, 98%. Offered by: TargetMol, GLPBio, Biosynth, Ambeed, Chemat. Available pack sizes: 1mg, 5mg, 10mg, 25mg, 50mg, 10mM (in 1ml dmso), 100mg, 100 mg.

S63845/ 98.56% (existing batch purity)
TargetMol
  • size: 1mg, 5mg, 10mg, 25mg
  • Variants: 5
from 698.07
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S63845
GLPBio
  • size: 1mg, 10mg, 10mM (in 1ml dmso), 25mg
  • Variants: 6
from 737.45
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S 63845
Biosynth
  • size: 50mg
  • Variants: 1
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S63845 98%
Ambeed
  • size: 100mg, 1mg, 5mg, 10mg
  • Variants: 6
from 437.12
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(αR)-α-[[(5S)-5-[3-Chloro-2-methyl-4-[2-(4-methyl-1-piperazinyl)ethoxy]phenyl]-6-(5-fluoro-2-furanyl)thieno[2,3-d]pyrimidin-4-yl]oxy]-2-[[1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl]methoxy]benzenepropanoic acid, 98%, 98%
Chemat
  • size: 1mg, 5mg, 10mg, 25mg
  • Variants: 6
from 434.00
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S63845, 99.94%
MedChemExpress
  • size: 100 mg, 10mM/1mL, 25 mg, 1 mg
  • Variants: 7
from 579.76
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Structural formula: {0} (CAS {1})

S63845 is a potent and selective myeloid cell leukemia 1 (MCL1) inhibitor with a Kd of 0.19 nM for human MCL1. S63845 is a small molecule that specifically binds with high affinity to the BH3-binding groove of MCL1. S63845 potently kills MCL1-dependent cancer cells, including multiple myeloma, leukaemia and lymphoma cells, by activating the BAX/BAK-dependent mitochondrial apoptotic pathway.

Source: ChEBI

Identity
Molecular formulaC39H37ClF4N6O6S
Molecular weight829.3 g/mol
IUPAC name(2R)-2-[5-[3-chloro-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(5-fluorofuran-2-yl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[[2-(2,2,2-trifluoroethyl)pyrazol-3-yl]methoxy]phenyl]propanoic acid
InChIKeyZFBHXVOCZBPADE-SSEXGKCCSA-N
SMILESCC1=C(C=CC(=C1Cl)OCCN2CCN(CC2)C)C3=C(SC4=NC=NC(=C34)O[C@H](CC5=CC=CC=C5OCC6=CC=NN6CC(F)(F)F)C(=O)O)C7=CC=C(O7)F

Computed by PubChem (NCBI)

Synonyms: C39H37ClF4N6O6S, ZFBHXVOCZBPADE-SSEXGKCCSA-N