TAS 6417

cas: 1661854-97-2 — see every product listed under this CAS number, including other names

TAS 6417 (CAS 1661854-97-2) is a chemical reagent available from Chemat. Available pack sizes: 10mg, 5mg, 25mg, 50mg, 100mg. Offered by: Biosynth.

brandBiosynth
catalog numberFT166464-10mg
cas1661854-97-2
size10mg
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properties

categoryLife Sciences
purityNo data
delivery time3-4 Weeks
Structural formula: {0} (CAS {1})

Zipalertinib is a member of the class of acrylamides that is (8S)-6-methyl-5-(quinolin-3-yl)-8,9-dihydropyrimido[5,4-b]indolizine-4,8-diamine in which the amino group at position 8S is substituted by an acryloyl group. It a covalent epidermal growth factor receptor inhibitor that targets exon 20 insertion mutations. It has a role as an antineoplastic agent, an apoptosis inducer and an epidermal growth factor receptor antagonist. It is a secondary carboxamide, a member of acrylamides, a member of quinolines, an organic heterotricyclic compound, an aromatic amine and a primary amino compound.

Source: ChEBI

Identity
Molecular formulaC23H20N6O
Molecular weight396.4 g/mol
IUPAC nameN-[(8S)-4-amino-6-methyl-5-quinolin-3-yl-8,9-dihydropyrimido[5,4-b]indolizin-8-yl]prop-2-enamide
InChIKeyMKCYPWYURWOKST-INIZCTEOSA-N
SMILESCC1=C[C@@H](CN2C1=C(C3=C(N=CN=C32)N)C4=CC5=CC=CC=C5N=C4)NC(=O)C=C

Computed by PubChem (NCBI)

Synonyms: Zipalertinib, Cln 081, Pan-EGFR Inhibitor CLN-081, Mutation-specific EGFR TKI TAS6417, EGFR Mutant-specific Inhibitor CLN-081, Pan-mutation-selective EGFR Inhibitor CLN-081, Pan-mutation-selective EGFR Tyrosine Kinase Inhibitor CLN-081, Zipalertinib [INN], zipalertinibum, Zipalertinib [WHO-DD]
Isomers (same molecular formula)
N-(2-aminophenyl)-4-[[(4-pyridin-3-ylpyrimidin-2-yl)amino]methyl]benzamide C23H20N6O
2-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-N-(5-pyrazin-2-yl-2-pyridinyl)acetamide C23H20N6O

Also listed as

Tas6417, 95% Combi-blocks CAS 1661854-97-2
TAS6417/ 99.19% (existing batch purity) TargetMol CAS 1661854-97-2
TAS6417 GLPBio CAS 1661854-97-2
2-Propenamide, N-[(8S)-4-amino-8,9-dihydro-6-methyl-5-(3-quinolinyl)pyrimido[5,4-b]indolizin-8-yl]-, 97%, 97% Chemat CAS 1661854-97-2
Zipalertinib, 99.62% MedChemExpress CAS 1661854-97-2
TAS 6417 hydrochloride Biosynth CAS 1661854-97-2 (free base)