TAS6417

cas: 1661854-97-2 — see every product listed under this CAS number, including other names

TAS6417 (CAS 1661854-97-2) is a chemical reagent available from Chemat. Available pack sizes: 10mg, 100mg, 10mM (in 1ml dmso), 25mg, 5mg, 50mg. Offered by: GLPBio.

brandGLPBio
catalog numberGC32752-10
cas1661854-97-2
size10mg
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Available pack sizes

brand size price
GLPBio 10mg 2520.73 Pln
GLPBio 100mg 9681.89 Pln
GLPBio 10mM (in 1ml dmso) 1804.61 Pln
GLPBio 25mg 4837.57 Pln
GLPBio 5mg 1678.24 Pln
GLPBio 50mg 6733.18 Pln

properties

purityNo data
delivery timeTo be confirmed by Chemat
Structural formula: {0} (CAS {1})

Zipalertinib is a member of the class of acrylamides that is (8S)-6-methyl-5-(quinolin-3-yl)-8,9-dihydropyrimido[5,4-b]indolizine-4,8-diamine in which the amino group at position 8S is substituted by an acryloyl group. It a covalent epidermal growth factor receptor inhibitor that targets exon 20 insertion mutations. It has a role as an antineoplastic agent, an apoptosis inducer and an epidermal growth factor receptor antagonist. It is a secondary carboxamide, a member of acrylamides, a member of quinolines, an organic heterotricyclic compound, an aromatic amine and a primary amino compound.

Source: ChEBI

Identity
Molecular formulaC23H20N6O
Molecular weight396.4 g/mol
IUPAC nameN-[(8S)-4-amino-6-methyl-5-quinolin-3-yl-8,9-dihydropyrimido[5,4-b]indolizin-8-yl]prop-2-enamide
InChIKeyMKCYPWYURWOKST-INIZCTEOSA-N
SMILESCC1=C[C@@H](CN2C1=C(C3=C(N=CN=C32)N)C4=CC5=CC=CC=C5N=C4)NC(=O)C=C

Computed by PubChem (NCBI)

Synonyms: Zipalertinib, Cln 081, Pan-EGFR Inhibitor CLN-081, Mutation-specific EGFR TKI TAS6417, EGFR Mutant-specific Inhibitor CLN-081, Pan-mutation-selective EGFR Inhibitor CLN-081, Pan-mutation-selective EGFR Tyrosine Kinase Inhibitor CLN-081, Zipalertinib [INN], zipalertinibum, Zipalertinib [WHO-DD]
Isomers (same molecular formula)
N-(2-aminophenyl)-4-[[(4-pyridin-3-ylpyrimidin-2-yl)amino]methyl]benzamide C23H20N6O
2-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-N-(5-pyrazin-2-yl-2-pyridinyl)acetamide C23H20N6O

Also listed as

Tas6417, 95% Combi-blocks CAS 1661854-97-2
TAS6417/ 99.19% (existing batch purity) TargetMol CAS 1661854-97-2
TAS 6417 Biosynth CAS 1661854-97-2
2-Propenamide, N-[(8S)-4-amino-8,9-dihydro-6-methyl-5-(3-quinolinyl)pyrimido[5,4-b]indolizin-8-yl]-, 97%, 97% Chemat CAS 1661854-97-2
Zipalertinib, 99.62% MedChemExpress CAS 1661854-97-2
TAS 6417 hydrochloride Biosynth CAS 1661854-97-2 (free base)