TAS-116

cas: 1260533-36-5 — see every product listed under this CAS number, including other names

TAS-116 (CAS 1260533-36-5) is a chemical reagent available from Chemat. Available pack sizes: 50mg, 25mg. Offered by: Biosynth.

brandBiosynth
catalog numberKAC53336-50mg
cas1260533-36-5
size50mg
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Available pack sizes

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Biosynth 25mg price on request

properties

categoryLife Sciences
purityNo data
delivery time3-4 Weeks
Structural formula: {0} (CAS {1})

Tas-116 is pimitespib is a specific inhibitor of heat shock protein 90 (Hsp90) subtypes alpha and beta, with potential antineoplastic and chemo/radiosensitizing activities. Upon oral administration, pimitespib specifically binds to and inhibits the activity of Hsp90 alpha and beta; this results in the proteasomal degradation of oncogenic client proteins, which inhibits client protein dependent-signaling, induces apoptosis, and inhibits the proliferation of cells overexpressing HSP90alpha/beta.

Source: ChEBI

Identity
Molecular formulaC25H26N8O
Molecular weight454.5 g/mol
IUPAC name3-ethyl-4-[4-[4-(1-methylpyrazol-4-yl)imidazol-1-yl]-3-propan-2-ylpyrazolo[3,4-b]pyridin-1-yl]benzamide
InChIKeyNVVPMZUGELHVMH-UHFFFAOYSA-N
SMILESCCC1=C(C=CC(=C1)C(=O)N)N2C3=NC=CC(=C3C(=N2)C(C)C)N4C=C(N=C4)C5=CN(N=C5)C

Computed by PubChem (NCBI)

Synonyms: Pimitespib, Heat Shock Protein 90 alpha/beta Inhibitor TAS-116, Jeselhy, Pimitespib (JAN), PIMITESPIB [JAN], Jeselhy (TN), PIMITESPIB [INN], Tas 116, PIMITESPIB [WHO-DD], Pimitespib, >98% (HPLC)
Isomers (same molecular formula)
N-(1-bicyclo[1.1.1]pentanylmethyl)-1-[2-[[4-(6-methoxyimidazo[1,5-a]pyridin-8-yl)triazol-1-yl]methyl]imidazo[1,2-a]pyridin-6-yl]methanamine C25H26N8O
(3R)-1'-[3-(3,4-dihydro-2H-1,5-naphthyridin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]spiro[3H-1-benzofuran-2,4'-piperidine]-3-amine C25H26N8O

Also listed as

Pimitespib/ 99.49% (existing batch purity) TargetMol CAS 1260533-36-5
Pimitespib, 99.15% MedChemExpress CAS 1260533-36-5
Pimitespib, 99% Ambeed CAS 1260533-36-5
3-Ethyl-4-(3-isopropyl-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl)benzamide, 99% BLDpharm CAS 1260533-36-5
3-Ethyl-4-(3-isopropyl-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl)benzamide, 98% Chemat CAS 1260533-36-5