Products 1260533-36-5
CAS 1260533-36-5 appears in our catalog under these names: Pimitespib/ 99.49% (existing batch purity), TAS-116, Pimitespib 99%, 3-Ethyl-4-(3-isopropyl-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl)benzamide, 98%, 98%, Pimitespib, 99.15%. Offered by: TargetMol, Biosynth, Ambeed, Chemat, MedChemExpress. Available pack sizes: 1mg, 5mg, 10mg, 25mg, 50mg, 1g, 100mg, 250mg.
Tas-116 is pimitespib is a specific inhibitor of heat shock protein 90 (Hsp90) subtypes alpha and beta, with potential antineoplastic and chemo/radiosensitizing activities. Upon oral administration, pimitespib specifically binds to and inhibits the activity of Hsp90 alpha and beta; this results in the proteasomal degradation of oncogenic client proteins, which inhibits client protein dependent-signaling, induces apoptosis, and inhibits the proliferation of cells overexpressing HSP90alpha/beta.
Source: ChEBI
| Molecular formula | C25H26N8O |
|---|---|
| Molecular weight | 454.5 g/mol |
| IUPAC name | 3-ethyl-4-[4-[4-(1-methylpyrazol-4-yl)imidazol-1-yl]-3-propan-2-ylpyrazolo[3,4-b]pyridin-1-yl]benzamide |
| InChIKey | NVVPMZUGELHVMH-UHFFFAOYSA-N |
| SMILES | CCC1=C(C=CC(=C1)C(=O)N)N2C3=NC=CC(=C3C(=N2)C(C)C)N4C=C(N=C4)C5=CN(N=C5)C |
Computed by PubChem (NCBI)