Products 755038-65-4
CAS 755038-65-4 appears in our catalog under these names: N-[trans-4-[4-(Cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-4-[[(7R)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pteridinyl]amino]-3-methoxybenzamide, 97%, 97%, Volasertib, >95% (HPLC), Volasertib/ 98.04% (existing batch purity), BI6727(Volasertib), Volasertib. Offered by: Chemat, TRC, TargetMol, GLPBio, Biosynth. Available pack sizes: 5mg, 10mg, 50mg, 100mg, 250mg, 1g, 25mg, 1mg.
Volasertib is a member of the class of pteridines that is (7R)-7-ethyl-5-methyl-8-(propan-2-yl)-7,8-dihydropteridin-6(5H)-one substituted by a [4-({trans-4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexyl}carbamoyl)-2-methoxyphenyl]amino group at position 2. It is as polo-like kinase 1 inhibitor (IC50 = 0.87 nM) with potential antineoplastic activity. It has a role as an EC 2.7.11.21 (polo kinase) inhibitor, an antineoplastic agent and an apoptosis inducer. It is a secondary carboxamide, a member of benzamides, a monomethoxybenzene, a member of piperazines, a member of pteridines, a substituted aniline, a secondary amino compound, a tertiary amino compound and a member of cyclopropanes.
Source: ChEBI
| Molecular formula | C34H50N8O3 |
|---|---|
| Molecular weight | 618.8 g/mol |
| IUPAC name | N-[4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexyl]-4-[[(7R)-7-ethyl-5-methyl-6-oxo-8-propan-2-yl-7H-pteridin-2-yl]amino]-3-methoxybenzamide |
| InChIKey | SXNJFOWDRLKDSF-XKHVUIRMSA-N |
| SMILES | CC[C@@H]1C(=O)N(C2=CN=C(N=C2N1C(C)C)NC3=C(C=C(C=C3)C(=O)NC4CCC(CC4)N5CCN(CC5)CC6CC6)OC)C |
Computed by PubChem (NCBI)