bis(7)–Tacrine

cas: 224445-12-9 — see every product listed under this CAS number, including other names

bis(7)–Tacrine (CAS 224445-12-9) is a chemical reagent available from Chemat. Available pack sizes: 10mg, 100mg, 5mg, 50mg. Offered by: GLPBio.

brandGLPBio
catalog numberGC15628-10
cas224445-12-9
size10mg
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Available pack sizes

brand size price
GLPBio 10mg 1402.09 Pln
GLPBio 100mg 7603.75 Pln
GLPBio 5mg 934.04 Pln
GLPBio 50mg 4533.34 Pln

properties

purityNo data
delivery timeTo be confirmed by Chemat
Structural formula: {0} (CAS {1})

Bis(7)-tacrine is a secondary amino compound consisting of two molecules of tacrine that are linked together through their exocyclic amino groups by a heptane-1,7-diyl chain. Bis(7)-tacrine is an acetylcholinesterase (AChE)inhibitor (IC50 0.40 nM, >1,000 times more potent than tacrine). It has also been found to protect against H2O2 -induced apoptosis in rat pheochromocytoma cells. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor, an EC 1.14.13.39 (nitric oxide synthase) inhibitor, a neuroprotective agent and an apoptosis inhibitor. It is functionally related to a tacrine.

Source: ChEBI

Identity
Molecular formulaC33H40N4
Molecular weight492.7 g/mol
IUPAC nameN,N'-bis(1,2,3,4-tetrahydroacridin-9-yl)heptane-1,7-diamine
InChIKeyITZOKHKOFJOBFS-UHFFFAOYSA-N
SMILESC1CCC2=NC3=CC=CC=C3C(=C2C1)NCCCCCCCNC4=C5CCCCC5=NC6=CC=CC=C64

Computed by PubChem (NCBI)

Synonyms: Bis(7)-tacrine, N,N'-Di-1,2,3,4-Tetrahydroacridin-9-Ylheptane-1,7-Diamine, Tacrine-Based Inhibitor 2f, N,N'-bis(1,2,3,4-tetrahydroacridin-9-yl)heptane-1,7-diamine, bis(7)-cognitin, Bis-7-Tacrine, 2ckm, Tacrine Dimer 3b, Heptylenebis-tacrine, heptylene-bis(tacrine)

Also listed as

bis(7)-Tacrine TargetMol CAS 224445-12-9
Bis(7)-tacrine (dihydrochloride), 99.9% MedChemExpress CAS 224445-12-9