Products 224445-12-9

CAS 224445-12-9 appears in our catalog under these names: bis(7)-Tacrine, bis(7)–Tacrine, Bis(7)-tacrine (dihydrochloride), 99.9%. Offered by: TargetMol, GLPBio, Biosynth, MedChemExpress. Available pack sizes: 5mg, 10mg, 100mg, 50mg, 5 mg.

bis(7)-Tacrine
TargetMol, Biosynth
  • size: 5mg, 10mg, 100mg, 50mg
  • Variants: 5
from 1448.25
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bis(7)–Tacrine
GLPBio
  • size: 10mg, 100mg, 5mg, 50mg
  • Variants: 4
from 934.04
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Bis(7)-tacrine (dihydrochloride), 99.9%
MedChemExpress
  • size: 5 mg
  • Variants: 1
from 1234.56
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Structural formula: {0} (CAS {1})

Bis(7)-tacrine is a secondary amino compound consisting of two molecules of tacrine that are linked together through their exocyclic amino groups by a heptane-1,7-diyl chain. Bis(7)-tacrine is an acetylcholinesterase (AChE)inhibitor (IC50 0.40 nM, >1,000 times more potent than tacrine). It has also been found to protect against H2O2 -induced apoptosis in rat pheochromocytoma cells. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor, an EC 1.14.13.39 (nitric oxide synthase) inhibitor, a neuroprotective agent and an apoptosis inhibitor. It is functionally related to a tacrine.

Source: ChEBI

Identity
Molecular formulaC33H40N4
Molecular weight492.7 g/mol
IUPAC nameN,N'-bis(1,2,3,4-tetrahydroacridin-9-yl)heptane-1,7-diamine
InChIKeyITZOKHKOFJOBFS-UHFFFAOYSA-N
SMILESC1CCC2=NC3=CC=CC=C3C(=C2C1)NCCCCCCCNC4=C5CCCCC5=NC6=CC=CC=C64

Computed by PubChem (NCBI)

Synonyms: Bis(7)-tacrine, N,N'-Di-1,2,3,4-Tetrahydroacridin-9-Ylheptane-1,7-Diamine, Tacrine-Based Inhibitor 2f, N,N'-bis(1,2,3,4-tetrahydroacridin-9-yl)heptane-1,7-diamine, bis(7)-cognitin, Bis-7-Tacrine, 2ckm, Tacrine Dimer 3b, Heptylenebis-tacrine, heptylene-bis(tacrine)