CAS 1032900-25-6 appears in our catalog under these names: Ceritinib, 5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine, >95% (HPLC), LDK378, Ceritinib/ 99.46% (existing batch purity), Ceritinib, 98%. Offered by: Chemat Brand, TRC, GLPBio, TargetMol, Biosynth. Available pack sizes: on request, 10mg, 25mg, 5mg, 1g, 200mg, 10mM (in 1ml dmso), 50mg.
Ceritinib is a member of the class of aminopyrimidines that is 2,6-diamino-5-chloropyrimidine in which the amino groups at positions 2 and 6 are respectively carrying 2-methoxy-4-(piperidin-4-yl)-5-methylphenyl and 2-(isopropylsulfonyl)phenyl substituents. Used for the treatment of ALK-positive metastatic non-small cell lung cancer. It has a role as an antineoplastic agent and an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor. It is a member of piperidines, an aromatic ether, a sulfone, an organochlorine compound, an aminopyrimidine and a secondary amino compound.
Source: ChEBI
| Molecular formula | C28H36ClN5O3S |
|---|---|
| Molecular weight | 558.1 g/mol |
| IUPAC name | 5-chloro-2-N-(5-methyl-4-piperidin-4-yl-2-propan-2-yloxyphenyl)-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine |
| InChIKey | VERWOWGGCGHDQE-UHFFFAOYSA-N |
| SMILES | CC1=CC(=C(C=C1C2CCNCC2)OC(C)C)NC3=NC=C(C(=N3)NC4=CC=CC=C4S(=O)(=O)C(C)C)Cl |
Computed by PubChem (NCBI)