Products 1173671-63-0

CAS 1173671-63-0 appears in our catalog under these names: Rhosin, Rhosin, 98.74%, (R,E)-2-Amino-3-(1H-indol-3-yl)-N'-(quinoxalin-6-ylmethylene)propanehydrazide, 98%. Offered by: GLPBio, MedChemExpress, Chemat. Available pack sizes: 10mg, 2mg, 5mg, 1 mg, 5 mg, 10mM/1mL, 25 mg, 10 mg.

Rhosin
GLPBio
  • size: 10mg, 2mg, 5mg
  • Variants: 3
from 1416.13
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Rhosin, 98.74%
MedChemExpress
  • size: 1 mg, 5 mg, 10mM/1mL, 25 mg
  • Variants: 5
from 1271.71
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(R,E)-2-Amino-3-(1H-indol-3-yl)-N'-(quinoxalin-6-ylmethylene)propanehydrazide, 98%
Chemat
  • size: 2mg, 5mg
  • Variants: 2
from 1307.60
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Structural formula: {0} (CAS {1})

Rhosin is a D-tryptophan derivative obtained by formal condensation of the carboxy group of D-tryptophan with the amino group of (quinoxalin-6-yl)methylidenehydrazide. It directly targets the Rho GEF binding domain, thereby preventing Rho from interacting with its GEFs. It has a role as a RhoA inhibitor, a RhoC inhibitor and an antineoplastic agent. It is a hydrazone, a quinoxaline derivative and a D-tryptophan derivative.

Source: ChEBI

Identity
Molecular formulaC20H18N6O
Molecular weight358.4 g/mol
IUPAC name(2R)-2-amino-3-(1H-indol-3-yl)-N-[(E)-quinoxalin-6-ylmethylideneamino]propanamide
InChIKeyFGYHLIHEFHCMPP-FVWOBLMASA-N
SMILESC1=CC=C2C(=C1)C(=CN2)C[C@H](C(=O)N/N=C/C3=CC4=NC=CN=C4C=C3)N

Computed by PubChem (NCBI)

Synonyms: Rhosin, (R,E)-2-amino-3-(1H-indol-3-yl)-N'-(quinoxalin-6-ylmethylene)propanehydrazide, D-tryptophan (2E)-2-(6-quinoxalinylmethylene)hydrazide, orb1706719, (quinoxalinylmethylidene-D-tryptophanyl)hydrazide, (2R)-2-amino-3-(1H-indol-3-yl)-N'-[(quinoxalin-6-yl)methylidene]propanehydrazide
Isomers (same molecular formula)
4-methyl-3-N-[4-[5-(4-methyl-1,2-oxazol-5-yl)-3-pyridinyl]pyrimidin-2-yl]benzene-1,3-diamine C20H18N6O
6-amino-5-[[4-(dimethylamino)phenyl]methylideneamino]-2-oxo-1-phenylpyrimidine-4-carbonitrile C20H18N6O