Products 1296270-45-5

CAS 1296270-45-5 appears in our catalog under these names: AZD 8186, (Rac)-AZD8186. Offered by: Biosynth, MedChemExpress. Available pack sizes: 10mg, 5mg, 25mg, 100mg, 50mg, Get quote.

AZD 8186
Biosynth
  • size: 10mg, 5mg, 25mg, 100mg
  • Variants: 5
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(Rac)-AZD8186
MedChemExpress
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  • Variants: 1
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Structural formula: {0} (CAS {1})

AZD8186 is a member of the class of chromones that is chromone substituted by morpholin-4-yl, dimethylaminoacyl, and (1R)-1-(3,5-difluoroanilino)ethyl groups at positions 2, 6, and 8, respectively. It is a potent inhibitor of PI3K-beta (IC50 = 4nM) and PI3K-delta (IC50 = 12nM) with selectivity over PI3K-alpha (IC50 = 35 nM) and PI3K-gamma (IC50 = 675 nM). It has a role as an antineoplastic agent and an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor. It is a tertiary carboxamide, a member of chromones, a difluorobenzene, a member of morpholines, a substituted aniline and a secondary amino compound.

Source: ChEBI

Identity
Molecular formulaC24H25F2N3O4
Molecular weight457.5 g/mol
IUPAC name8-[1-(3,5-difluoroanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide
InChIKeyLMJFJIDLEAWOQJ-UHFFFAOYSA-N
SMILESCC(C1=CC(=CC2=C1OC(=CC2=O)N3CCOCC3)C(=O)N(C)C)NC4=CC(=CC(=C4)F)F

Computed by PubChem (NCBI)

Synonyms: rac-AZD8186, (Rac)-AZD8186, LMJFJIDLEAWOQJ-UHFFFAOYSA-N, s7694
Related forms of this compound
8-[(1R)-1-(3,5-difluoroanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide C24H25F2N3O4