Products 1346574-57-9
CAS 1346574-57-9 appears in our catalog under these names: GSK126, GSK126/ 99.43% (existing batch purity), GSK 126, GSK126 98%, 1H-Indole-4-carboxamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-6-[6-(1-piperazinyl)-3-pyridinyl]-, 98%, 98%. Offered by: TRC, TargetMol, GLPBio, Biosynth, Ambeed. Available pack sizes: 10mg, 1mg, 5mg, 2mg, 25mg, 50mg, 100mg, 200mg.
GSK126 is a member of the class of methylindoles that is 1H-indole substituted by (2S)-butan-2-yl, methyl, N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]acetamide, and 6-(piperazin-1-yl)pyridin-3-yl groups at positions 1, 3, 4, and 6, respectively. It is a potent and highly selective inhibitor of EZH2 methyltransferase (IC50 = 9.9 nM). It has a role as an antiatherosclerotic agent, an EC 2.1.1.43 (enhancer of zeste homolog 2) inhibitor, an antineoplastic agent, an angiogenesis inhibitor, a neuroprotective agent and an anti-obesity agent. It is a secondary carboxamide, a member of pyridines, a pyridone, a methylindole and a N-arylpiperazine.
Source: ChEBI
| Molecular formula | C31H38N6O2 |
|---|---|
| Molecular weight | 526.7 g/mol |
| IUPAC name | 1-[(2S)-butan-2-yl]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-methyl-6-(6-piperazin-1-yl-3-pyridinyl)indole-4-carboxamide |
| InChIKey | FKSFKBQGSFSOSM-QFIPXVFZSA-N |
| SMILES | CC[C@H](C)N1C=C(C2=C(C=C(C=C21)C3=CN=C(C=C3)N4CCNCC4)C(=O)NCC5=C(C=C(NC5=O)C)C)C |
Computed by PubChem (NCBI)