Products 135722-25-7
CAS 135722-25-7 appears in our catalog under these names: S 14506 HCl, S 14506, S-14506. Offered by: TargetMol, GLPBio, MedChemExpress. Available pack sizes: 1mg, 5mg, 10mg, Get quote.
4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide is a benzamide obtained by formal condensation of the carboxy group of 4-fluorobenzoic acid with the primary amino group of 2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethylamine. Highly potent selective 5-HT1A receptor full agonist (pKi values are 9.0, 6.6, 7.5, 6.6 and < 6.0 for 5-HT1A, 5-HT1B, 5-HT1C, 5-HT2 and 5-HT3 receptors respectively). Possibly binds between the agonist binding site and the G protein interaction switch site, affecting the activation mechanism, and may display positive cooperativity. Anxiolytic following central administration in vivo. It has a role as an anxiolytic drug and a serotonergic agonist. It is a member of benzamides, an organofluorine compound, a N-alkylpiperazine, a N-arylpiperazine and a methoxynaphthalene. It is a conjugate base of a 4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide(1+).
Source: ChEBI
| Molecular formula | C24H26FN3O2 |
|---|---|
| Molecular weight | 407.5 g/mol |
| IUPAC name | 4-fluoro-N-[2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl]benzamide |
| InChIKey | IFMQODYDAUKKEN-UHFFFAOYSA-N |
| SMILES | COC1=CC2=C(C=CC=C2N3CCN(CC3)CCNC(=O)C4=CC=C(C=C4)F)C=C1 |
Computed by PubChem (NCBI)
Synonyms:
4-fluoro-N-[2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl]benzamide, N-(2-(4-(7-Methoxy-1-naphthyl)piperazino)ethyl)-4-fluorobenzamide, 4-Fluoro-N-(2-(4-(7-methoxy-1-naphthyl)piperazine-1-yl)ethyl)benzamide, 4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide, Benzamide, 4-fluoro-N-(2-(4-(7-methoxy-1-naphthalenyl)-1-piperazinyl)ethyl)-, 4-Fluoro-N-{2-[4-(7-methoxy-naphthalen-1-yl)-piperazin-1-yl]-ethyl}-benzamide, Tocris-1771, orb1699433, S 14506 HCl, 1-[2-(4-fluorobenzoylamino)ethyl]-4-(7-methoxynaphtyl)piperazine