Products 1474034-05-3

CAS 1474034-05-3 appears in our catalog under these names: Rta-408, 95%, Omaveloxolone (RTA–408), Omaveloxolone/ 98.7% (existing batch purity), Omaveloxolone 99%, N-((4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-Cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-hexadecahydropicen-4a(2H)-yl)-2,2-difluoropropanamide, 99%, 99%. Offered by: Combi-blocks, GLPBio, TargetMol, Ambeed, Chemat. Available pack sizes: 250mg, 100mg, 10mg, 2mg, 25mg, 5mg, 10mM (in 1ml dmso), 50mg.

Rta-408, 95%
Combi-blocks
  • size: 250mg, 100mg
  • Variants: 2
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Omaveloxolone (RTA–408)
GLPBio
  • size: 10mg, 2mg, 25mg, 5mg
  • Variants: 6
from 737.45
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Omaveloxolone/ 98.7% (existing batch purity)
TargetMol
  • size: 1mg, 2mg, 5mg, 10mg
  • Variants: 8
from 439.25
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Omaveloxolone 99%
Ambeed
  • size: 1mg, 5mg, 10mg, 25mg
  • Variants: 7
from 186.81
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N-((4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-Cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-hexadecahydropicen-4a(2H)-yl)-2,2-difluoropropanamide, 99%, 99%
Chemat
  • size: 1mg, 5mg, 10mg, 25mg
  • Variants: 8
from 146.00
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Omaveloxolone, 99.52%
MedChemExpress
  • size: 500 mg, 1 g, 5 mg, 100 mg
  • Variants: 9
from 649.42
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Omaveloxolone, 99%
Fluorochem
  • size: 5mg, 10mg, 25mg, 50mg
  • Variants: 6
from 289.50
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Structural formula: {0} (CAS {1})

Omaveloxolone is a semi-synthetic triterpenoid drug. It is an Nrf2 activator that is approved for the treatment of Friedreich's ataxia in adults and adolescents aged 16 years and older. It has a role as an antioxidant, an antineoplastic agent, an anti-inflammatory agent and a cardioprotective agent. It is a secondary carboxamide, a nitrile, a pentacyclic triterpenoid, a cyclic terpene ketone and an organofluorine compound. It derives from a hydride of an oleanane.

Source: ChEBI

Identity
Molecular formulaC33H44F2N2O3
Molecular weight554.7 g/mol
IUPAC nameN-[(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,7,8,8a,14a,14b-decahydropicen-4a-yl]-2,2-difluoropropanamide
InChIKeyRJCWBNBKOKFWNY-IDPLTSGASA-N
SMILESC[C@@]12CC[C@]3(CCC(C[C@H]3[C@H]1C(=O)C=C4[C@]2(CC[C@@H]5[C@@]4(C=C(C(=O)C5(C)C)C#N)C)C)(C)C)NC(=O)C(C)(F)F

Computed by PubChem (NCBI)

Synonyms: Omaveloxolone, SKYCLARYS, omaveloxolona, omaveloxolonum, N-(2-cyano-3,12-dioxo-28-noroleana-1,9(11)-dien-17-yl)-2,2-difluoropropanamide, Nrf1-activator-1, Omaveloxolone [INN], Omaveloxolone (RTA-408), Skyclarys (TN), Omaveloxolone (USAN/INN)