Products 220997-97-7
CAS 220997-97-7 appears in our catalog under these names: Difloomotecan, Diflomotecan. Offered by: TRC, GLPBio, Biosynth, MedChemExpress. Available pack sizes: 250mg, 100mg, 10mg, 5mg, 25mg, 50mg, Get quote.
Diflomotecan is an organic heteropentacyclic compound that is (5R)-8-[(6,7-difluoroquinolin-3-yl)methyl]-5-ethyl-5-hydroxy-1,4,5,8-tetrahydrooxepino[3,4-c]pyridine-3,9-dione in which position 7 of the oxepinopyridine moiety is joined to position 3 of the difluoroquinoine ring by a single bond. An E-ring modified camptothecin analogue that has greater lactone stability in plasma compared with other topoisomerase I inhibitors. It has a role as an antineoplastic agent and an EC 5.99.1.2 (DNA topoisomerase) inhibitor. It is a tertiary alcohol, an organofluorine compound, an organonitrogen heterocyclic compound, an organic heteropentacyclic compound and an epsilon-lactone. It is functionally related to a (R)-homocamptothecin.
Source: ChEBI
| Molecular formula | C21H16F2N2O4 |
|---|---|
| Molecular weight | 398.4 g/mol |
| IUPAC name | (20R)-20-ethyl-6,7-difluoro-20-hydroxy-17-oxa-3,13-diazapentacyclo[11.9.0.02,11.04,9.015,21]docosa-1(22),2(11),3,5,7,9,15(21)-heptaene-14,18-dione |
| InChIKey | LFQCJSBXBZRMTN-OAQYLSRUSA-N |
| SMILES | CC[C@]1(CC(=O)OCC2=C1C=C3C4=C(CN3C2=O)C=C5C=C(C(=CC5=N4)F)F)O |
Computed by PubChem (NCBI)