CAS 2252403-56-6 appears in our catalog under these names: (S)-AMG-510/ 98.57% (existing batch purity), AMG–510 racemate, AMG 510 racemate, Sotorasib racemate 99%, Pyrido[2,3-d]pyrimidin-2(1H)-one, 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-, 98%, 98%. Offered by: TargetMol, GLPBio, Biosynth, Ambeed, Chemat. Available pack sizes: 2mg, 5mg, 10mg, 25mg, 50mg, 100mg, 500mg, 10mM (in 1ml dmso).
Sotorasib is a pyridopyrimidine that is pyrido[2,3-d]pyrimidin-2(1H)-one substituted by 4-methyl-2-(propan-2-yl)pyridin-3-yl, (2S)-2-methyl-4-(prop-2-enoyl)piperazin-1-yl, fluoro and 2-fluoro-6-hydroxyphenyl groups at positions 1, 4, 6 and 7, respectively. It is approved for the treatment of patients with non-small cell lung cancer having KRASG12C mutations. It has a role as an antineoplastic agent. It is a tertiary carboxamide, a member of acrylamides, a member of methylpyridines, a member of phenols, a pyridopyrimidine, a N-acylpiperazine, a tertiary amino compound and a member of monofluorobenzenes.
Source: ChEBI
| Molecular formula | C30H30F2N6O3 |
|---|---|
| Molecular weight | 560.6 g/mol |
| IUPAC name | 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-propan-2-yl-3-pyridinyl)-4-[(2S)-2-methyl-4-prop-2-enoylpiperazin-1-yl]pyrido[2,3-d]pyrimidin-2-one |
| InChIKey | NXQKSXLFSAEQCZ-SFHVURJKSA-N |
| SMILES | C[C@H]1CN(CCN1C2=NC(=O)N(C3=NC(=C(C=C32)F)C4=C(C=CC=C4F)O)C5=C(C=CN=C5C(C)C)C)C(=O)C=C |
Computed by PubChem (NCBI)