Products 2628280-40-8

CAS 2628280-40-8 appears in our catalog under these names: Nirmatrelvir, PF–07321332, Nirmatrelvir/ 99.51% (existing batch purity), Paxlovid, PF-07321332 98%. Offered by: Chemat Brand, GLPBio, TargetMol, Biosynth, Ambeed. Available pack sizes: on request, 10mg, 100mg, 5mg, 10mM (in 1ml dmso), 50mg, 1mg, 2mg.

Nirmatrelvir
Chemat Brand, HPC Standards
  • size: on request, 1x10mg
  • Variants: 2
from 649.64
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PF–07321332
GLPBio
  • size: 10mg, 100mg, 5mg, 10mM (in 1ml dmso)
  • Variants: 5
from 765.54
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Nirmatrelvir/ 99.51% (existing batch purity)
TargetMol
  • size: 1mg, 2mg, 5mg, 10mg
  • Variants: 9
from 532.05
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Paxlovid
Biosynth
  • size: 0,5g, 1g, 2g, 5g
  • Variants: 5
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PF-07321332 98%
Ambeed
  • size: 100mg, 250mg, 1g, 5g
  • Variants: 5
from 437.12
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3-Azabicyclo[3.1.0]hexane-2-carboxamide, N-[(1S)-1-cyano-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]-3-[(2S)-3,3-dimethyl-1-oxo-2-[(2,2,2-trifluoroacetyl)amino]butyl]-6,6-dimethyl-, (1R,2S,5S)-, 97%, 97%
Chemat
  • size: 100mg, 250mg, 1g, 5g
  • Variants: 5
from 146.00
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Nirmatrelvir, Concentration: 100 µg/ml Solvent: Methanol
HPC Standards
  • size: 1x1ml
  • Variants: 1
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Nirmatrelvir, 99.83%
MedChemExpress
  • size: 10mM/1mL, 5 mg, 100 mg, 10 mg
  • Variants: 5
from 839.82
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Nirmatrelvir (Standard), 99.98%
MedChemExpress
  • size: 5 mg, 100 mg, 10 mg, 50 mg
  • Variants: 5
from 1559.64
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Structural formula: {0} (CAS {1})

Nirmatrelvir is an azabicyclohexane that is (1R,5S)-3-azabicyclo[3.1.0]hexane substituted by {(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl}aminoacyl, 3-methyl-N-(trifluoroacetyl)-L-valinamide, methyl and methyl groups at positions 2S, 3, 6 and 6, respectively. It is the first orally administered inhibitor of SARS-CoV-2 main protease developed by Pfizer and used in combination with ritonavir for the treatment of COVID-19. It has a role as an EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor and an anticoronaviral agent. It is a secondary carboxamide, a tertiary carboxamide, an azabicyclohexane, a nitrile, an organofluorine compound, a pyrrolidinecarboxamide and a member of pyrrolidin-2-ones.

Source: ChEBI

Identity
Molecular formulaC23H32F3N5O4
Molecular weight499.5 g/mol
IUPAC name(1R,2S,5S)-N-[(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl]-3-[(2S)-3,3-dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
InChIKeyLIENCHBZNNMNKG-OJFNHCPVSA-N
SMILESCC1([C@@H]2[C@H]1[C@H](N(C2)C(=O)[C@H](C(C)(C)C)NC(=O)C(F)(F)F)C(=O)N[C@@H](C[C@@H]3CCNC3=O)C#N)C

Computed by PubChem (NCBI)

Synonyms: Nirmatrelvir, Paxlovid, PAXLOVID COMPONENT NIRMATRELVIR, NIRMATRELVIR COMPONENT OF PAXLOVID, SARS-CoV-2 3CLpro Inhibitor PF-07321332, SARS-CoV-2-3CL Protease Inhibitor PF-07321332, Nirmatrelvir [USAN], Paxlovid-d9, Boceprevir Impurity 5, Nirmatrelvir (Standard)
Related forms of this compound
(1R,2S,5S)-N-[(1R)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl]-3-[(2S)-3,3-dimethyl-2-[(2,2,2-trifluoroacetyl)amino]butanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide C23H32F3N5O4