Products 269055-15-4
CAS 269055-15-4 appears in our catalog under these names: 4-((6-AMINO-5-BROMO-2-((4-CYANOPHENYL)A&, 4-[[6-Amino-5-bromo-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3,5-dimethylbenzonitrile, 98%, 98%, Etravirine, Etravirine, >95% (HPLC), Etravirine/ 99.56% (existing batch purity). Offered by: Sigma-Aldrich, Chemat, Chemat Brand, TRC, TargetMol. Available pack sizes: 100MG, 5mg, 10mg, 50mg, 250mg, 1g, 5g, 10g.
Etravirine is an aminopyrimidine that consists of 2,6-diaminopyrimidine bearing a bromo substituent at position 5, a 4-cyano-2,6-dimethylphenoxy substituent at position 4 and having a 4-cyanophenyl substituent attached to the 2-amino group. NNRTI of HIV-1, binds directly to RT and blocks RNA-dependent and DNA-dependent DNA polymerase activities. It has a role as an antiviral agent and a HIV-1 reverse transcriptase inhibitor. It is an aromatic ether, an organobromine compound, an aminopyrimidine and a dinitrile.
Source: ChEBI
| Molecular formula | C20H15BrN6O |
|---|---|
| Molecular weight | 435.3 g/mol |
| IUPAC name | 4-[6-amino-5-bromo-2-(4-cyanoanilino)pyrimidin-4-yl]oxy-3,5-dimethylbenzonitrile |
| InChIKey | PYGWGZALEOIKDF-UHFFFAOYSA-N |
| SMILES | CC1=CC(=CC(=C1OC2=NC(=NC(=C2Br)N)NC3=CC=C(C=C3)C#N)C)C#N |
Computed by PubChem (NCBI)
Synonyms:
Etravirine, Intelence, Etravirina, 4-[6-amino-5-bromo-2-(4-cyanoanilino)pyrimidin-4-yl]oxy-3,5-dimethylbenzonitrile, 4-(6-Amino-5-bromo-2-(4-cyanoanilino)pyrimidin-4-yloxy)-3,5-dimethylbenzonitrile, etravirinum, 4-(6-amino-5-bromo-2-(4-cyanoanilino)pyrimidin-4-yl)oxy-3,5-dimethylbenzonitrile, Etravirine (TMC125), Etravirine-d8, C20H15BrN6O