Products 57132-53-3
CAS 57132-53-3 is the registry number for Proglumetacin. Offered by: MedChemExpress. Available pack sizes: Get quote.
Proglumetacin is a carboxylic ester obtained by formal condensation of the carboxy group of indometacin with the hydroxy group of 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl N2-benzoyl-N,N-dipropyl-alpha-glutaminate. Used (as its dimaleate salt) to control pain and inflammation associated with musculoskeletal and joint disorders. Following oral administration, it is metabolised to indometacin and proglumide, a drug with antisecretory effects that helps prevent injury to the stomach lining. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antipyretic, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, a lipoxygenase inhibitor and a prodrug. It is a member of benzamides, a carboxylic ester, an aromatic ether, a N-alkylpiperazine, a N-acylindole and a member of monochlorobenzenes. It is functionally related to a proglumide and an indometacin.
Source: ChEBI
| Molecular formula | C46H58ClN5O8 |
|---|---|
| Molecular weight | 844.4 g/mol |
| IUPAC name | 3-[4-[2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyethyl]piperazin-1-yl]propyl 4-benzamido-5-(dipropylamino)-5-oxopentanoate |
| InChIKey | PTXGHCGBYMQQIG-UHFFFAOYSA-N |
| SMILES | CCCN(CCC)C(=O)C(CCC(=O)OCCCN1CCN(CC1)CCOC(=O)CC2=C(N(C3=C2C=C(C=C3)OC)C(=O)C4=CC=C(C=C4)Cl)C)NC(=O)C5=CC=CC=C5 |
Computed by PubChem (NCBI)