Products 57186-25-1
CAS 57186-25-1 appears in our catalog under these names: Paxilline, Paxilline, >95% (HPLC), Paxilline, 97+% , Paxilline, 97.50%, PAXILLINE, POWDER, >=98% (HPLC). Offered by: GLPBio, TRC, Thermo Scientific (Alfa Aesar), Chemat, Sigma-Aldrich. Available pack sizes: 1mg, 5mg, 10mg, 10 mg, 50 mg, 25 mg, 10mM/1mL, 5 mg.
Paxilline is an indole diterpene alkaloid with formula C27H33NO4 isolated from Penicillium paxilli. It is a potent inhibitor of large conductance Ca2+- and voltage-activated K+ (BK)-type channels. It has a role as a geroprotector, a mycotoxin, an anticonvulsant, a potassium channel blocker, a genotoxin, an EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor, an Aspergillus metabolite and a Penicillium metabolite. It is a diterpene alkaloid, a tertiary alcohol, an enone, an organic heterohexacyclic compound and a terpenoid indole alkaloid.
Source: ChEBI
| Molecular formula | C27H33NO4 |
|---|---|
| Molecular weight | 435.6 g/mol |
| IUPAC name | (1S,2R,5S,7R,11S,14S)-11-hydroxy-7-(2-hydroxypropan-2-yl)-1,2-dimethyl-6-oxa-23-azahexacyclo[12.10.0.02,11.05,10.016,24.017,22]tetracosa-9,16(24),17,19,21-pentaen-8-one |
| InChIKey | ACNHBCIZLNNLRS-UBGQALKQSA-N |
| SMILES | C[C@]12CC[C@H]3C(=CC(=O)[C@H](O3)C(C)(C)O)[C@@]1(CC[C@@H]4[C@@]2(C5=C(C4)C6=CC=CC=C6N5)C)O |
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