Products 625115-52-8

CAS 625115-52-8 appears in our catalog under these names: Riociguat EP Impurity A (N-Desmethyl Riociguat), N-Desmethyl Riociguat, >95% (HPLC), Nelociguat/ 99.15% (existing batch purity), Nelociguat (BAY60–4552), Nelociguat 98%. Offered by: Chemat Brand, TRC, TargetMol, GLPBio, Ambeed. Available pack sizes: on request, 100mg, 10mg, 50mg, 1mg, 5mg, 25mg, 200mg.

Riociguat EP Impurity A (N-Desmethyl Riociguat)
Chemat Brand
  • size: on request
  • Variants: 1
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N-Desmethyl Riociguat, >95% (HPLC)
TRC
  • size: 100mg, 10mg, 50mg
  • Variants: 3
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Nelociguat/ 99.15% (existing batch purity)
TargetMol
  • size: 1mg, 5mg, 10mg, 25mg
  • Variants: 8
from 392.86
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Nelociguat (BAY60–4552)
GLPBio
  • size: 10mg, 100mg, 5mg, 50mg
  • Variants: 4
from 774.90
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Nelociguat 98%
Ambeed
  • size: 100mg, 250mg, 1g, 5g
  • Variants: 4
from 264.69
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Methyl (4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)carbamate, 98%, 98%
Chemat
  • size: 100mg, 250mg, 1g
  • Variants: 3
from 213.20
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Nelociguat, 99.73%
MedChemExpress
  • size: 10mM/1mL, 25 mg, 100 mg, 50 mg
  • Variants: 6
from 361.49
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Nelociguat, 98%
Fluorochem
  • size: 100mg, 1g
  • Variants: 2
from 383.22
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Structural formula: {0} (CAS {1})

Nelociguat is a member of the class of pyrazolopyridines that is 1H-pyrazolo[3,4-b]pyridine which is substituted by a 2-fluorobenzyl and 4,6-diamino-5-[(methoxycarbonyl)amino]pyrimidin-2-yl groups at positions 1 and 3, respectively. It is an active metabolite of riociguat and a soluble guanylate cyclase stimulator developed by Bayer for the treatment of erectile dysfunction and heart failure. It has a role as a vasodilator agent, an antihypertensive agent, a drug metabolite and a soluble guanylate cyclase activator. It is a carbamate ester, an aminopyrimidine, a pyrazolopyridine and a member of monofluorobenzenes.

Source: ChEBI

Identity
Molecular formulaC19H17FN8O2
Molecular weight408.4 g/mol
IUPAC namemethyl N-[4,6-diamino-2-[1-[(2-fluorophenyl)methyl]pyrazolo[5,4-b]pyridin-3-yl]pyrimidin-5-yl]carbamate
InChIKeyFTQHGWIXJSSWOY-UHFFFAOYSA-N
SMILESCOC(=O)NC1=C(N=C(N=C1N)C2=NN(C3=C2C=CC=N3)CC4=CC=CC=C4F)N

Computed by PubChem (NCBI)

Synonyms: Nelociguat, Bay 60-4552, Bay-60-4552, nelociguatum, N-Desmethyl riociguat, Nelociguat [INN], Riociguat EP Impurity A, Riociguat Impurity H, N-Desmethyl-riociguat, NELOCIGUAT [WHO-DD]