CAS 755038-02-9 appears in our catalog under these names: 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, 95%, BI 2536, BI 2536/ 98.63% (existing batch purity), BI 2536, BI-2536, 95%. Offered by: Combi-blocks, GLPBio, TargetMol, Biosynth, Thermo Scientific (Acros). Available pack sizes: 50mg, 100mg, 25mg, 5mg, 10mM (in 1ml dmso), 1mg, 2mg, 10mg.
BI-2536 is a member of the class of tetrahydropterins that is 7,8-dihydropteridin-6(5H)-one substituted by {2-methoxy-4-[(1-methylpiperidin-4-yl)carbamoyl]phenyl}amino, methyl, ethyl, and cyclopentyl groups at positions 2, 5, 7R, and 8, respectively. It is a polo-like kinase 1 (PLK1) inhibitor with antineoplastic activity. It has a role as an EC 2.7.11.21 (polo kinase) inhibitor, an antineoplastic agent and an apoptosis inducer. It is a secondary carboxamide, a member of benzamides, a member of cyclopentanes, a monomethoxybenzene, a member of piperidines, a tetrahydropterin, a substituted aniline, a secondary amino compound and a tertiary amino compound.
Source: ChEBI
| Molecular formula | C28H39N7O3 |
|---|---|
| Molecular weight | 521.7 g/mol |
| IUPAC name | 4-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide |
| InChIKey | XQVVPGYIWAGRNI-JOCHJYFZSA-N |
| SMILES | CC[C@@H]1C(=O)N(C2=CN=C(N=C2N1C3CCCC3)NC4=C(C=C(C=C4)C(=O)NC5CCN(CC5)C)OC)C |
Computed by PubChem (NCBI)