CAS 81093-37-0 appears in our catalog under these names: Pravastatin, 98%, Pravastatin, Pravastatin, 98.38%. Offered by: AmBeed, GLPBio, Biosynth, MedChemExpress, Fluorochem. Available pack sizes: 10g, 1g, 5g, 10mg, 100mg, 25mg, 50mg, 250g.
Pravastatin is a carboxylic ester resulting from the formal condensation of (S)-2-methylbutyric acid with the hydroxy group adjacent to the ring junction of (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid. Derived from microbial transformation of mevastatin, pravastatin is a reversible inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA). The sodium salt is used for lowering cholesterol and preventing cardiovascular disease. It is one of the lower potency statins, but has the advantage of fewer side effects compared with lovastatin and simvastatin. It has a role as a metabolite, a xenobiotic, an anticholesteremic drug and an environmental contaminant. It is a carboxylic ester, a secondary alcohol, a hydroxy monocarboxylic acid, a carbobicyclic compound, a 3-hydroxy carboxylic acid and a statin (semi-synthetic). It is functionally related to a (S)-2-methylbutyric acid and a (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid. It is a conjugate acid of a pravastatin(1-).
Source: ChEBI
| Molecular formula | C23H36O7 |
|---|---|
| Molecular weight | 424.5 g/mol |
| IUPAC name | (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-[(2S)-2-methylbutanoyl]oxy-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid |
| InChIKey | TUZYXOIXSAXUGO-PZAWKZKUSA-N |
| SMILES | CC[C@H](C)C(=O)O[C@H]1C[C@@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@H](C[C@H](CC(=O)O)O)O)O |
Computed by PubChem (NCBI)