Products 905579-51-3

CAS 905579-51-3 appears in our catalog under these names: MLN 4924, Pevonedistat/ 99.2% (existing batch purity), MLN4924, MLN 4924, 98.00%, Pevonedistat 98%. Offered by: TRC, TargetMol, GLPBio, Biosynth, Chemat. Available pack sizes: 1mg, 2mg, 5mg, 10mg, 25mg, 50mg, 100mg, 10mM (in 1ml dmso).

MLN 4924
TRC, Biosynth
  • size: 1mg, 10mg, 5mg, 25mg
  • Variants: 5
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Pevonedistat/ 99.2% (existing batch purity)
TargetMol
  • size: 1mg, 2mg, 5mg, 10mg
  • Variants: 7
from 499.07
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MLN4924
GLPBio
  • size: 1mg, 10mg, 100mg, 5mg
  • Variants: 6
from 583.00
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MLN 4924, 98.00%
Chemat
  • size: 5mg
  • Variants: 1
from 1379.95
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Pevonedistat 98%
Ambeed
  • size: 1g, 1mg, 5mg, 10mg
  • Variants: 8
from 242.44
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Sulfamic acid, [(1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl ester, 98%, 98%
Chemat
  • size: 5mg, 10mg, 25mg, 50mg
  • Variants: 7
from 405.20
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Pevonedistat, 99.98%
MedChemExpress
  • size: 500 mg, 10 mg, 200 mg, 10mM/1mL
  • Variants: 9
from 407.93
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Pevonedistat (Standard)
MedChemExpress
  • size: 100 mg, 50 mg, 10 mg, 25 mg
  • Variants: 5
from 1559.64
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PEVONEDISTAT, 99%
Fluorochem
  • size: 5mg, 10mg, 25mg, 50mg
  • Variants: 5
from 747.67
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Structural formula: {0} (CAS {1})

Pevonedistat is a pyrrolopyrimidine that is 7H-pyrrolo[2,3-d]pyrimidine which is substituted by a (1S)-2,3-dihydro-1H-inden-1-ylnitrilo group at position 4 and by a (1S,3S,4S)-3-hydroxy-4-[(sulfamoyloxy)methyl]cyclopentyl group at position 7. It is a potent and selective NEDD8-activating enzyme inhibitor with an IC50 of 4.7 nM, and currently under clinical investigation for the treatment of acute myeloid leukemia (AML) and myelodysplastic syndromes. It has a role as an antineoplastic agent and an apoptosis inducer. It is a member of cyclopentanols, a pyrrolopyrimidine, a member of indanes, a secondary amino compound and a sulfamidate.

Source: ChEBI

Identity
Molecular formulaC21H25N5O4S
Molecular weight443.5 g/mol
IUPAC name[(1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl sulfamate
InChIKeyMPUQHZXIXSTTDU-QXGSTGNESA-N
SMILESC1CC2=CC=CC=C2[C@H]1NC3=C4C=CN(C4=NC=N3)[C@@H]5C[C@H]([C@H](C5)O)COS(=O)(=O)N

Computed by PubChem (NCBI)

Synonyms: Pevonedistat, pevonedistatum, Nedd8-Activating Enzyme Inhibitor MLN4924, Pevonedistat (MLN-4924), Pevonedistat HCl, Pevonedistat [USAN:INN], 3gzn, 905579-51-3 (free base), Pevonedistat; MLN4924, Pevonedistat (USAN/INN)