Products 952021-60-2
CAS 952021-60-2 appears in our catalog under these names: Pf 477736, 95%, PF–477736, PF 477736/ 98.34% (existing batch purity), PF-477736, PF-477736 97%. Offered by: Combi-blocks, GLPBio, TargetMol, Chemat, Ambeed. Available pack sizes: 100mg, 10mg, 5mg, 10mM (in 1ml dmso), 50mg, 2mg, 25mg, 1mg.
PF-00477736 is a diazepinoindole that is 8-amino-4,5-dihydro-6H-[1,2]diazepino[4,5,6-cd]indol-6-one which is substituted at position 2 by a 1-methylpyrazol-4-yl group and in which the amino group at position 8 has undergone condensation with the carboxy group of (2R)-2-cyclohexylglycine to give the corresponding carboxamide. It is an inhibitor of checkpoint kinase 1 (Chk 1). It has a role as an antineoplastic agent and an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor. It is a diazepinoindole, an amino acid amide and a member of pyrazoles.
Source: ChEBI
| Molecular formula | C22H25N7O2 |
|---|---|
| Molecular weight | 419.5 g/mol |
| IUPAC name | (2R)-2-amino-2-cyclohexyl-N-[2-(1-methylpyrazol-4-yl)-9-oxo-3,10,11-triazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13),11-pentaen-6-yl]acetamide |
| InChIKey | NDEXUOWTGYUVGA-LJQANCHMSA-N |
| SMILES | CN1C=C(C=N1)C2=C3C=NNC(=O)C4=C3C(=CC(=C4)NC(=O)[C@@H](C5CCCCC5)N)N2 |
Computed by PubChem (NCBI)
Synonyms:
952021-60-2 (free base), orb1301138