16a-Methyl-9,11-dehydro prednisolone

cas: 13209-41-1 — see every product listed under this CAS number, including other names

16a-Methyl-9,11-dehydro prednisolone (CAS 13209-41-1) is a chemical reagent available from Chemat. Available pack sizes: 50mg, 25mg, 100mg, 250mg. Offered by: Biosynth.

brandBiosynth
catalog numberFM25760-50mg
cas13209-41-1
size50mg
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properties

categoryLife Sciences
purityNo data
delivery time1-2 weeks
Structural formula: {0} (CAS {1})

Vamorolone is a 3-oxo-1,4-steroid that is pregna-1,4,9(11)-trien-17-ol substituted by oxo, oxo, and hydroxy groups at positions 3, 20, and 21, respectively. It is approved by the FDA for the treatment of patients with Duchenne muscular dystrophy aged 2 years and older. It has a role as an anti-inflammatory drug, an immunosuppressive agent and a glucocorticoid receptor agonist. It is a primary alpha-hydroxy ketone, a tertiary alpha-hydroxy ketone, a 17alpha-hydroxy steroid, a 21-hydroxy steroid, a 20-oxo steroid, a corticosteroid and a 3-oxo-Delta(1),Delta(4)-steroid.

Source: ChEBI

Identity
Molecular formulaC22H28O4
Molecular weight356.5 g/mol
IUPAC name(8S,10S,13S,14S,16R,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-3-one
InChIKeyZYTXTXAMMDTYDQ-DGEXFFLYSA-N
SMILESC[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4(C3=CC[C@@]2([C@]1(C(=O)CO)O)C)C

Computed by PubChem (NCBI)

Synonyms: vamorolone, Agamree, vamorolona, 17,21-Dihydroxy-16alpha-methylpregna-1,4,9(11)-triene-3,20-dione, vamorolonum, 9,11-dehydro dexamethasone, (16alpha)-17,21-dihydroxy-16-methylpregna-1,4,9(11)-triene-3,20-dione, Vamorolone [USAN], Dexamethasone EP Impurity E, 16a-Methyl-9,11-dehydro Prednisolone
Related forms of this compound
(8S,10S,13S,14S,16S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-3-one C22H28O4
Isomers (same molecular formula)
(8S,9S,10R,13S,14S,16S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-3-one C22H28O4
1-(3,4-dimethoxyphenyl)-3-ethyl-5,6-dimethoxy-2-methyl-2,3-dihydro-1H-indene C22H28O4
[(6S,8R,9S,10R,13S,14S,17R)-17-ethynyl-6-hydroxy-13-methyl-3-oxo-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl] acetate C22H28O4
(2Z)-2-hydroxy-2-[(6S,8S,9S,10R,11S,13S,14S)-11-hydroxy-6,10,13-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-ylidene]acetaldehyde C22H28O4
(1S,2S,8S,10S,11S,14R,15S,17S)-14-acetyl-14-hydroxy-2,8,15-trimethyl-18-oxapentacyclo[8.8.0.01,17.02,7.011,15]octadeca-3,6-dien-5-one C22H28O4
(1S,2S,10S,11S,13R,14R,15S,17S)-14-acetyl-14-hydroxy-2,13,15-trimethyl-18-oxapentacyclo[8.8.0.01,17.02,7.011,15]octadeca-3,6-dien-5-one C22H28O4
(1S,2S,11S,13R,14S,15S,17S)-14-(2-hydroxyacetyl)-2,13,15-trimethyl-18-oxapentacyclo[8.8.0.01,17.02,7.011,15]octadeca-3,6-dien-5-one C22H28O4
(6S,8S,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-6,10,13-trimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione C22H28O4
[(6R,8R,9S,10R,13S,14S,17R)-17-ethynyl-6-hydroxy-13-methyl-3-oxo-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl] acetate C22H28O4
(8S,9S,10R,11R,13S,14S,17R)-11-hydroxy-10,13-dimethylspiro[2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthrene-17,5'-oxolane]-2',3-dione C22H28O4
(2S,10S,11S,14R,15S)-14-acetyl-14-hydroxy-2,13,15-trimethyl-18-oxapentacyclo[8.8.0.01,17.02,7.011,15]octadeca-3,6-dien-5-one C22H28O4

Also listed as

Vamorolone GLPBio CAS 13209-41-1
Dexamethasone EP Impurity E Chemat Brand CAS 13209-41-1
16Alpha-Methyl-9,11-dehydro Prednisolone, >95% (HPLC) TRC CAS 13209-41-1
Vamorolone/ 98.04% (existing batch purity) TargetMol CAS 13209-41-1
16a-Methyl-9,11-dehydro prednisolone - Bio-X â„¢ Biosynth CAS 13209-41-1
(16α)-17,21-Dihydroxy-16-methylpregna-1,4,9(11)-triene-3,20-dione, 98%, 98% Chemat CAS 13209-41-1
Vamorolone, 99.48% MedChemExpress CAS 13209-41-1
Vamorolone (Standard) MedChemExpress CAS 13209-41-1
Vamorolone, 97% Fluorochem CAS 13209-41-1