2-Fluoro-9-(5-O-phosphono-β-D-arabinofuranosyl)-9H-purin-6-amine, 98%
cas: 75607-67-9 — see every product listed under this CAS number, including other names
2-Fluoro-9-(5-O-phosphono-β-D-arabinofuranosyl)-9H-purin-6-amine, 98% (CAS 75607-67-9) is a chemical reagent available from Chemat. Available pack sizes: 1mg, 10mg, 50mg, 100mg, 250mg, 1g, 5g. Offered by: Chemat.
| brand | Chemat |
|---|---|
| catalog number | Ch11ICN0-1mg |
| cas | 75607-67-9 |
| size | 1mg |
| availability | 50g |
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Available pack sizes
| brand | size | price | |
|---|---|---|---|
| Chemat | 1mg | 88.40 Pln | |
| Chemat | 10mg | 93.20 Pln | |
| Chemat | 50mg | 102.80 Pln | |
| Chemat | 100mg | 112.40 Pln | |
| Chemat | 250mg | 141.20 Pln | |
| Chemat | 1g | 366.80 Pln | |
| Chemat | 5g | 1187.60 Pln |
properties
| purity | 98% |
|---|---|
| delivery time | 3 weeks |
Fludarabine phosphate is a purine arabinonucleoside monophosphate having 2-fluoroadenine as the nucleobase. A prodrug, it is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. Once incorporated into DNA, 2-fluoro-ara-ATP functions as a DNA chain terminator. It is used for the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to, or whose disease has progressed during, treatment with at least one standard alkylating-agent containing regimenas. It has a role as an antiviral agent, an antimetabolite, an antineoplastic agent, an immunosuppressive agent, a prodrug and a DNA synthesis inhibitor. It is an organofluorine compound, a purine arabinonucleoside monophosphate and a nucleoside analogue. It is functionally related to a 2-fluoroadenine.
Source: ChEBI
| Molecular formula | C10H13FN5O7P |
|---|---|
| Molecular weight | 365.21 g/mol |
| IUPAC name | [(2R,3S,4S,5R)-5-(6-amino-2-fluoropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate |
| InChIKey | GIUYCYHIANZCFB-FJFJXFQQSA-N |
| SMILES | C1=NC2=C(N=C(N=C2N1[C@H]3[C@H]([C@@H]([C@H](O3)COP(=O)(O)O)O)O)F)N |
Computed by PubChem (NCBI)
Synonyms:
fludarabine phosphate, fludara, Fludarabine 5'-monophosphate, Oforta, Fludarabine monophosphate, 2-F-ara-AMP, 2-Fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl)-9H-purin-6-amine, 2F-ara-AMP, 9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-(dihydrogen phosphate), 9H-Purin-6-amine, 2-fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl)-