Fludarabine Phosphate (Fludara)

cas: 75607-67-9 — see every product listed under this CAS number, including other names

Fludarabine Phosphate (Fludara) (CAS 75607-67-9) is a chemical reagent available from Chemat. Available pack sizes: 10mg, 200mg, 10mM (in 1ml dmso), 50mg. Offered by: GLPBio.

brandGLPBio
catalog numberGC15134-10
cas75607-67-9
size10mg
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Available pack sizes

brand size price
GLPBio 10mg 648.53 Pln
GLPBio 200mg 1795.25 Pln
GLPBio 10mM (in 1ml dmso) 578.32 Pln
GLPBio 50mg 1154.02 Pln

properties

purityNo data
delivery timeTo be confirmed by Chemat
Structural formula: {0} (CAS {1})

Fludarabine phosphate is a purine arabinonucleoside monophosphate having 2-fluoroadenine as the nucleobase. A prodrug, it is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. Once incorporated into DNA, 2-fluoro-ara-ATP functions as a DNA chain terminator. It is used for the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to, or whose disease has progressed during, treatment with at least one standard alkylating-agent containing regimenas. It has a role as an antiviral agent, an antimetabolite, an antineoplastic agent, an immunosuppressive agent, a prodrug and a DNA synthesis inhibitor. It is an organofluorine compound, a purine arabinonucleoside monophosphate and a nucleoside analogue. It is functionally related to a 2-fluoroadenine.

Source: ChEBI

Identity
Molecular formulaC10H13FN5O7P
Molecular weight365.21 g/mol
IUPAC name[(2R,3S,4S,5R)-5-(6-amino-2-fluoropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
InChIKeyGIUYCYHIANZCFB-FJFJXFQQSA-N
SMILESC1=NC2=C(N=C(N=C2N1[C@H]3[C@H]([C@@H]([C@H](O3)COP(=O)(O)O)O)O)F)N

Computed by PubChem (NCBI)

Synonyms: fludarabine phosphate, fludara, Fludarabine 5'-monophosphate, Oforta, Fludarabine monophosphate, 2-F-ara-AMP, 2-Fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl)-9H-purin-6-amine, 2F-ara-AMP, 9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-(dihydrogen phosphate), 9H-Purin-6-amine, 2-fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl)-
Related forms of this compound
[(2R,3S,4R,5R)-5-(6-amino-2-fluoropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate C10H13FN5O7P
Isomers (same molecular formula)
[5-(2-amino-6-oxo-1H-purin-9-yl)-4-fluoro-3-hydroxyoxolan-2-yl]methyl dihydrogen phosphate C10H13FN5O7P

Also listed as

Fludarabine Phosphate, >95% (HPLC) TRC CAS 75607-67-9
Fludarabine Phosphate Mikromol CAS 75607-67-9
Fludarabine Phosphate/ 99.25% (existing batch purity) TargetMol CAS 75607-67-9
Fludarabine Monophosphate, >98.0%(HPLC)(T) TCI CAS 75607-67-9
Fludarabine phosphate, 98.00% Chemat CAS 75607-67-9
Fludarabine (phosphate), 99.77% MedChemExpress CAS 75607-67-9
Fludarabine (phosphate) (Standard) MedChemExpress CAS 75607-67-9
Fludarabine phosphate, 98% Fluorochem CAS 75607-67-9
2-Fluoro-9-(5-O-phosphono-β-D-arabinofuranosyl)-9H-purin-6-amine, 98% Chemat CAS 75607-67-9
((2R,3S,4S,5R)-5-(6-Amino-2-fluoro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, 98% BLDpharm CAS 75607-67-9