Acalabrutinib

cas: 1420477-60-6 — see every product listed under this CAS number, including other names

Acalabrutinib (CAS 1420477-60-6) is a chemical reagent available from Chemat. Available pack sizes: on request, 50mg, 25mg, 100mg, 250mg, 1000mg. Offered by: Chemat Brand, Biosynth.

brandChemat Brand
catalog numberULA001001
cas1420477-60-6
sizeon request
availability Do potwierdzenia przez Chemat|To be confirmed by Chemat
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Available pack sizes

brand size price
Chemat Brand on request price on request
Biosynth 50mg price on request
Biosynth 25mg price on request
Biosynth 100mg price on request
Biosynth 250mg price on request
Biosynth 1000mg price on request

properties

purityNo data
categoryChemicals
delivery timeTo be confirmed by Chemat
Structural formula: {0} (CAS {1})

Acalabrutinib is a member of the class of imidazopyrazines that is imidazo[1,5-a]pyrazine substituted by 4-(pyridin-2-ylcarbamoyl)phenyl, (2S)-1-(but-2-ynoyl)pyrrolidin-2-yl, and amino groups at positions 1, 3 and 8, respectively. It is an irreversible second-generation Bruton's tyrosine kinase (BTK) inhibitor that is approved by the FDA for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. It has a role as an antineoplastic agent, an apoptosis inducer and an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. It is a secondary carboxamide, a tertiary carboxamide, a member of benzamides, a member of pyridines, an aromatic amine, an imidazopyrazine, a pyrrolidinecarboxamide and a ynone.

Source: ChEBI

Identity
Molecular formulaC26H23N7O2
Molecular weight465.5 g/mol
IUPAC name4-[8-amino-3-[(2S)-1-but-2-ynoylpyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-N-pyridin-2-ylbenzamide
InChIKeyWDENQIQQYWYTPO-IBGZPJMESA-N
SMILESCC#CC(=O)N1CCC[C@H]1C2=NC(=C3N2C=CN=C3N)C4=CC=C(C=C4)C(=O)NC5=CC=CC=N5

Computed by PubChem (NCBI)

Synonyms: Acalabrutinib, acalabrutinibum, Bruton Tyrosine Kinase Inhibitor ACP-196, Calquence, Acalabrutinib (ACP-196), Acalabrutinib [INN], Acalabrutinib [USAN:INN], Acalabrutinib(ACP196), Acalabrutinib (JAN/USAN/INN), Calquence (TN)

Also listed as

Acalabrutinib, >95% (HPLC) TRC CAS 1420477-60-6
Acalabrutinib/ 99.95% (existing batch purity) TargetMol CAS 1420477-60-6
ACP–196 GLPBio CAS 1420477-60-6
Acalabrutinib, 98% Thermo Scientific (Acros) CAS 1420477-60-6
Acalabrutinib 98% Ambeed CAS 1420477-60-6
4-[8-Amino-3-[(2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl]-N-2-pyridinylbenzamide, 98%, 98% Chemat CAS 1420477-60-6
Acalabrutinib, 99.88% MedChemExpress CAS 1420477-60-6
Acalabrutinib (Standard) MedChemExpress CAS 1420477-60-6