Afatinib

cas: 439081-18-2 — see every product listed under this CAS number, including other names

Afatinib (CAS 439081-18-2) is a chemical reagent available from Chemat. Available pack sizes: 10mg, 1mg, 5mg. Offered by: Chemat.

brandChemat
catalog numberCM61500W-10mg
cas439081-18-2
size10mg
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Available pack sizes

brand size price
Chemat 10mg 2292.20 Pln
Chemat 1mg 994.04 Pln
Chemat 5mg 1426.15 Pln

properties

delivery time1-2 weeks
purityno data
categoryChemicals
Structural formula: {0} (CAS {1})

Afatinib is a quinazoline compound having a 3-chloro-4-fluoroanilino group at the 4-position, a 4-dimethylamino-trans-but-2-enamido group at the 6-position, and an (S)-tetrahydrofuran-3-yloxy group at the 7-position. Used (as its dimaleate salt) for the first-line treatment of patients with metastatic non-small cell lung cancer. It has a role as an antineoplastic agent and a tyrosine kinase inhibitor. It is a secondary carboxamide, a member of furans, an aromatic ether, an organofluorine compound, a member of quinazolines, a tertiary amino compound, an enamide and a member of monochlorobenzenes.

Source: ChEBI

Identity
Molecular formulaC24H25ClFN5O3
Molecular weight485.9 g/mol
IUPAC name(E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide
InChIKeyULXXDDBFHOBEHA-CWDCEQMOSA-N
SMILESCN(C)C/C=C/C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[C@H]4CCOC4

Computed by PubChem (NCBI)

Synonyms: Afatinib, Tomtovok, afatinibum, Tovok, (E/Z)-Afatinib, Afatinib (BIBW2992), Afatinib free base, Afatinib, Free Base, C24H25ClFN5O3, Afatinib [USAN:INN]
Related forms of this compound
(E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3R)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide C24H25ClFN5O3
(E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide C24H25ClFN5O3
(Z)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide C24H25ClFN5O3
(E)-4-[bis(trideuteriomethyl)amino]-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]but-2-enamide C24H25ClFN5O3

Also listed as

Afatinib, 98% Combi-blocks CAS 439081-18-2
(S)-Afatinib/ 99.96% (existing batch purity) TargetMol CAS 439081-18-2
Afatinib(BIBW2992) GLPBio CAS 439081-18-2
(E/Z)-Afatinib 98% Ambeed CAS 439081-18-2
N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide, 99%, 99% Chemat CAS 439081-18-2
(E/Z)-Afatinib, 99.98% MedChemExpress CAS 439081-18-2
(E/Z)-Afatinib (Standard) MedChemExpress CAS 439081-18-2
N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide, 98% Fluorochem CAS 439081-18-2