Alvocidib (Flavopiridol)

cas: 146426-40-6 — see every product listed under this CAS number, including other names

Alvocidib (Flavopiridol) (CAS 146426-40-6) is a chemical reagent available from Chemat. Available pack sizes: on request. Offered by: Chemat Brand.

brandChemat Brand
catalog numberULA251001
cas146426-40-6
sizeon request
availability Do potwierdzenia przez Chemat|To be confirmed by Chemat
Need more information?

Ask us about this product — we're happy to help.

Available pack sizes

brand size price
Chemat Brand on request price on request

properties

purityNo data
categoryChemicals
delivery timeTo be confirmed by Chemat
Structural formula: {0} (CAS {1})

Alvocidib is a synthetic dihydroxyflavone that is 5,7-dihydroxyflavone which is substituted by a 3-hydroxy-1-methylpiperidin-4-yl group at position 8 and by a chlorine at the 2' position (the ()-3S,4R stereoisomer). A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation. It has a role as an antineoplastic agent, an antirheumatic drug, an apoptosis inducer and an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor. It is a dihydroxyflavone, a hydroxypiperidine, a tertiary amino compound and a member of monochlorobenzenes. It is a conjugate base of an alvocidib(1+).

Source: ChEBI

Identity
Molecular formulaC21H20ClNO5
Molecular weight401.8 g/mol
IUPAC name2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]chromen-4-one
InChIKeyBIIVYFLTOXDAOV-YVEFUNNKSA-N
SMILESCN1CC[C@@H]([C@@H](C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O

Computed by PubChem (NCBI)

Synonyms: Flavopiridol, Alvocidib, Alvocidib freebase, alvocidibum, Flavopiridol (Alvocidib), ALVOCIDIB [MART.], Alvocidib [INN], Flavoperidol, Alvocidib [USAN], Alvocidib [USAN:INN]
Isomers (same molecular formula)
(Z)-but-2-enedioic acid;(2S,6S)-9-chloro-4-methyl-13-oxa-4-azatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),7(12),8,10,14,16-hexaene C21H20ClNO5
2-(2-chlorophenyl)-5,7-dihydroxy-8-[(2S,3R)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl]chromen-4-one C21H20ClNO5
(Z)-but-2-enedioic acid;(2R,6R)-9-chloro-4-methyl-13-oxa-4-azatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),7(12),8,10,14,16-hexaene C21H20ClNO5
(E)-but-2-enedioic acid;(2S,6S)-9-chloro-4-methyl-13-oxa-4-azatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),7(12),8,10,14,16-hexaene C21H20ClNO5
(Z)-but-2-enedioic acid;(2S,6R)-9-chloro-4-methyl-13-oxa-4-azatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),7(12),8,10,14,16-hexaene C21H20ClNO5
3,16,17-trimethoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2,4(8),9,14,16,18,20-octaene chloride C21H20ClNO5

Also listed as

Flavopiridol/ 99.85% (existing batch purity) TargetMol CAS 146426-40-6
Flavopiridol GLPBio CAS 146426-40-6
Flavopiridol 98% Ambeed CAS 146426-40-6
2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one, 98%, 98% Chemat CAS 146426-40-6
Flavopiridol, 99.72% MedChemExpress CAS 146426-40-6
Flavopiridol (Standard) MedChemExpress CAS 146426-40-6