Flavopiridol

cas: 146426-40-6 — see every product listed under this CAS number, including other names

Flavopiridol (CAS 146426-40-6) is a chemical reagent available from Chemat. Available pack sizes: 10mg, 100mg, 5mg, 10mM (in 1ml dmso), 50mg, 1mg, 2mg, 25mg. Offered by: GLPBio, Biosynth.

brandGLPBio
catalog numberGC16063-10
cas146426-40-6
size10mg
Need more information?

Ask us about this product — we're happy to help.

Available pack sizes

brand size price
GLPBio 10mg 643.84 Pln
GLPBio 100mg 1593.99 Pln
GLPBio 5mg 578.32 Pln
GLPBio 10mM (in 1ml dmso) 592.36 Pln
GLPBio 50mg 1266.35 Pln
Biosynth 1mg price on request
Biosynth 2mg price on request
Biosynth 5mg price on request
Biosynth 25mg price on request
Biosynth 10mg price on request

properties

purityNo data
delivery timeTo be confirmed by Chemat
Structural formula: {0} (CAS {1})

Alvocidib is a synthetic dihydroxyflavone that is 5,7-dihydroxyflavone which is substituted by a 3-hydroxy-1-methylpiperidin-4-yl group at position 8 and by a chlorine at the 2' position (the ()-3S,4R stereoisomer). A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation. It has a role as an antineoplastic agent, an antirheumatic drug, an apoptosis inducer and an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor. It is a dihydroxyflavone, a hydroxypiperidine, a tertiary amino compound and a member of monochlorobenzenes. It is a conjugate base of an alvocidib(1+).

Source: ChEBI

Identity
Molecular formulaC21H20ClNO5
Molecular weight401.8 g/mol
IUPAC name2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]chromen-4-one
InChIKeyBIIVYFLTOXDAOV-YVEFUNNKSA-N
SMILESCN1CC[C@@H]([C@@H](C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O

Computed by PubChem (NCBI)

Synonyms: Flavopiridol, Alvocidib, Alvocidib freebase, alvocidibum, Flavopiridol (Alvocidib), ALVOCIDIB [MART.], Alvocidib [INN], Flavoperidol, Alvocidib [USAN], Alvocidib [USAN:INN]
Isomers (same molecular formula)
(Z)-but-2-enedioic acid;(2S,6S)-9-chloro-4-methyl-13-oxa-4-azatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),7(12),8,10,14,16-hexaene C21H20ClNO5
2-(2-chlorophenyl)-5,7-dihydroxy-8-[(2S,3R)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl]chromen-4-one C21H20ClNO5
(Z)-but-2-enedioic acid;(2R,6R)-9-chloro-4-methyl-13-oxa-4-azatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),7(12),8,10,14,16-hexaene C21H20ClNO5
(E)-but-2-enedioic acid;(2S,6S)-9-chloro-4-methyl-13-oxa-4-azatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),7(12),8,10,14,16-hexaene C21H20ClNO5
(Z)-but-2-enedioic acid;(2S,6R)-9-chloro-4-methyl-13-oxa-4-azatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),7(12),8,10,14,16-hexaene C21H20ClNO5

Also listed as

Alvocidib (Flavopiridol) Chemat Brand CAS 146426-40-6
Flavopiridol/ 99.85% (existing batch purity) TargetMol CAS 146426-40-6
Flavopiridol 98% Ambeed CAS 146426-40-6
2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one, 98%, 98% Chemat CAS 146426-40-6
Flavopiridol, 99.72% MedChemExpress CAS 146426-40-6
Flavopiridol (Standard) MedChemExpress CAS 146426-40-6