CB 839

cas: 1439399-58-2 — see every product listed under this CAS number, including other names

CB 839 (CAS 1439399-58-2) is a chemical reagent available from Chemat. Available pack sizes: 100mg, 50mg, 250mg, 500mg, 1000mg. Offered by: Biosynth.

brandBiosynth
catalog numberFC103571-100mg
cas1439399-58-2
size100mg
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properties

categoryLife Sciences
purityNo data
delivery time3-4 Weeks
Structural formula: {0} (CAS {1})

Telaglenastat is an orally bioavailable inhibitor of glutaminase, with potential antineoplastic activity. Upon oral administration, CB-839 selectively and irreversibly inhibits glutaminase, a mitochondrial enzyme that is essential for the conversion of the amino acid glutamine into glutamate. By blocking glutamine utilization, proliferation in rapidly growing cells is impaired. Glutamine-dependent tumors rely on the conversion of exogenous glutamine into glutamate and glutamate metabolites to both provide energy and generate building blocks for the production of macromolecules, which are needed for cellular growth and survival. It has a role as an EC 3.5.1.2 (glutaminase) inhibitor.

Source: ChEBI

Identity
Molecular formulaC26H24F3N7O3S
Molecular weight571.6 g/mol
IUPAC nameN-[6-[4-[5-[(2-pyridin-2-ylacetyl)amino]-1,3,4-thiadiazol-2-yl]butyl]pyridazin-3-yl]-2-[3-(trifluoromethoxy)phenyl]acetamide
InChIKeyPRAAPINBUWJLGA-UHFFFAOYSA-N
SMILESC1=CC=NC(=C1)CC(=O)NC2=NN=C(S2)CCCCC3=NN=C(C=C3)NC(=O)CC4=CC(=CC=C4)OC(F)(F)F

Computed by PubChem (NCBI)

Synonyms: Telaglenastat, telaglenastatum, Telaglenastat [USAN], Telaglenast at, PRAAPINBUWJLGA-UHFFFAOYSA-N, Telaglenastat (CB-839), TELAGLENASTAT [INN], Telaglenastat (USAN/INN), TELAGLENASTAT [WHO-DD], orb1226277
Isomers (same molecular formula)
2-[4-(1,3-dimethyl-5-oxo-1,2,4-triazol-4-yl)phenyl]-1-(2-methoxyethyl)-N-(5-methyl-1,3,4-thiadiazol-2-yl)-5-(trifluoromethyl)indole-7-carboxamide C26H24F3N7O3S

Also listed as

2-(Pyridin-2-yl)-N-(5-(4-(6-(2-(3-(trifluoromethoxy)phenyl)acetamido)pyridazin-3-yl)butyl)-1,3,4-thiadiazol-2-yl)acetamide, 98% BLDpharm CAS 1439399-58-2
2-Pyridineacetamide, N-[5-[4-[6-[[2-[3-(trifluoromethoxy)phenyl]acetyl]amino]-3-pyridazinyl]butyl]-1,3,4-thiadiazol-2-yl]-, 98% 2-Pyridineacetamide, N-[5-[4-[6-[[2-[3-(trifluoromethoxy)phenyl]acetyl]amino]-3-pyridazinyl]butyl]-1,3,4-thiadiazol-2-yl]-, 98% Fluorochem CAS 1439399-58-2
CB–839 GLPBio CAS 1439399-58-2
CB-839, >95% (HPLC) TRC CAS 1439399-58-2
Telaglenastat/ 99.89% (existing batch purity) TargetMol CAS 1439399-58-2
CB-839, 98%, 98% Chemat CAS 1439399-58-2
Telaglenastat, 99.92% MedChemExpress CAS 1439399-58-2
Telaglenastat (Standard) MedChemExpress CAS 1439399-58-2
Telaglenastat, 98% Ambeed CAS 1439399-58-2
GLS1 Inhibitor III, CB-839 1PC X 10MG Sigma-Aldrich CAS 1439399-58-2
CB-839, 98% Chemat CAS 1439399-58-2