CB-839, >95% (HPLC)

cas: 1439399-58-2 — see every product listed under this CAS number, including other names

CB-839, >95% (HPLC) (CAS 1439399-58-2) is a chemical reagent available from Chemat. Available pack sizes: 10mg, 1mg, 5mg. Offered by: TRC.

brandTRC
catalog numberTRC-C227095-10MG
cas1439399-58-2
size10mg
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Available pack sizes

brand size price
TRC 10mg price on request
TRC 1mg price on request
TRC 5mg price on request

properties

purity>95% (HPLC)
delivery timeTo be confirmed by Chemat
Structural formula: {0} (CAS {1})

Telaglenastat is an orally bioavailable inhibitor of glutaminase, with potential antineoplastic activity. Upon oral administration, CB-839 selectively and irreversibly inhibits glutaminase, a mitochondrial enzyme that is essential for the conversion of the amino acid glutamine into glutamate. By blocking glutamine utilization, proliferation in rapidly growing cells is impaired. Glutamine-dependent tumors rely on the conversion of exogenous glutamine into glutamate and glutamate metabolites to both provide energy and generate building blocks for the production of macromolecules, which are needed for cellular growth and survival. It has a role as an EC 3.5.1.2 (glutaminase) inhibitor.

Source: ChEBI

Identity
Molecular formulaC26H24F3N7O3S
Molecular weight571.6 g/mol
IUPAC nameN-[6-[4-[5-[(2-pyridin-2-ylacetyl)amino]-1,3,4-thiadiazol-2-yl]butyl]pyridazin-3-yl]-2-[3-(trifluoromethoxy)phenyl]acetamide
InChIKeyPRAAPINBUWJLGA-UHFFFAOYSA-N
SMILESC1=CC=NC(=C1)CC(=O)NC2=NN=C(S2)CCCCC3=NN=C(C=C3)NC(=O)CC4=CC(=CC=C4)OC(F)(F)F

Computed by PubChem (NCBI)

Synonyms: Telaglenastat, telaglenastatum, Telaglenastat [USAN], Telaglenast at, PRAAPINBUWJLGA-UHFFFAOYSA-N, Telaglenastat (CB-839), TELAGLENASTAT [INN], Telaglenastat (USAN/INN), TELAGLENASTAT [WHO-DD], orb1226277
Isomers (same molecular formula)
2-[4-(1,3-dimethyl-5-oxo-1,2,4-triazol-4-yl)phenyl]-1-(2-methoxyethyl)-N-(5-methyl-1,3,4-thiadiazol-2-yl)-5-(trifluoromethyl)indole-7-carboxamide C26H24F3N7O3S

Also listed as

2-Pyridineacetamide, N-[5-[4-[6-[[2-[3-(trifluoromethoxy)phenyl]acetyl]amino]-3-pyridazinyl]butyl]-1,3,4-thiadiazol-2-yl]-, 98% Fluorochem CAS 1439399-58-2
CB–839 GLPBio CAS 1439399-58-2
Telaglenastat/ 99.89% (existing batch purity) TargetMol CAS 1439399-58-2
CB 839 Biosynth CAS 1439399-58-2
Telaglenastat 98% Ambeed CAS 1439399-58-2
CB-839, 98%, 98% Chemat CAS 1439399-58-2
Telaglenastat, 99.92% MedChemExpress CAS 1439399-58-2
Telaglenastat (Standard) MedChemExpress CAS 1439399-58-2