CAS 56-94-0 appears in our catalog under these names: Demecarium bromide, 95%, Demecarium Bromide, Demecarium bromide/ 98%, Demecarium Bromide (BC–48), Demecarium Bromide, 95.0%. Offered by: Combi-blocks, TRC, Mikromol, LoGiCal, TargetMol. Available pack sizes: 100mg, 10mg, 50mg, 5mg, 25mg, 10mM (in 1ml dmso), 250mg, 5 mg.
Demecarium bromide is the methobromide salt of the N,N'-bis[3-(dimethylamino)phenyl carbamate] derivative of 2,13-diazatetradecane. It is an inhibitor of acetylcholinesterase and pseudocholinesterase, with a long duration of action. It is used in the treatment of chronic open-angle glaucoma: in the eye, it causes constriction of the iris sphincter muscle and the ciliary muscle, facilitating the outflow of the aqueous humor and so reducing intraocular pressure. It has a role as an EC 3.1.1.8 (cholinesterase) inhibitor and an EC 3.1.1.7 (acetylcholinesterase) inhibitor. It is a bromide salt, a carbamate ester and a quaternary ammonium salt. It contains a demarcarium.
Source: ChEBI
| Molecular formula | C32H52Br2N4O4 |
|---|---|
| Molecular weight | 716.6 g/mol |
| IUPAC name | trimethyl-[3-[methyl-[10-[methyl-[3-(trimethylazaniumyl)phenoxy]carbonylamino]decyl]carbamoyl]oxyphenyl]azanium dibromide |
| InChIKey | YHKBUDZECQDYBR-UHFFFAOYSA-L |
| SMILES | CN(CCCCCCCCCCN(C)C(=O)OC1=CC=CC(=C1)[N+](C)(C)C)C(=O)OC2=CC=CC(=C2)[N+](C)(C)C.[Br-].[Br-] |
Computed by PubChem (NCBI)