Entrectinib (Standard)
cas: 1108743-60-7 — see every product listed under this CAS number, including other names
Entrectinib (Standard) (CAS 1108743-60-7) is a chemical reagent available from Chemat. Available pack sizes: 25 mg, 50 mg, 10 mg, 100 mg, 5 mg. Offered by: MedChemExpress.
| brand | MedChemExpress |
|---|---|
| catalog number | HY-12678R-25 mg |
| cas | 1108743-60-7 |
| size | 25 mg |
| availability | Get quote |
Need more information?
Ask us about this product — we're happy to help.
Available pack sizes
| brand | size | price | |
|---|---|---|---|
| MedChemExpress | 25 mg | 2019.40 Pln | |
| MedChemExpress | 50 mg | 2776.37 Pln | |
| MedChemExpress | 10 mg | 1308.86 Pln | |
| MedChemExpress | 100 mg | 3844.49 Pln | |
| MedChemExpress | 5 mg | 909.48 Pln |
properties
| delivery time | over 3 weeks |
|---|---|
| purity | no data |
Entrectinib is a member of the class of indazoles that is 1H-indazole substituted by [4-(4-methylpiperazin-1-yl)-2-(tetrahydro-2H-pyran-4-ylamino)benzoyl]amino and 3,5-difluorobenzyl groups at positions 3 and 5, respectively. It is a potent inhibitor of TRKA, TRKB, TRKC, ROS1, and ALK (IC50 values of 0.1 to 1.7 nM), and used for the treatment of NTRK, ROS1 and ALK gene fusion-positive solid tumours. It has a role as an antibacterial agent, an antineoplastic agent, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and an apoptosis inducer. It is a secondary carboxamide, a member of benzamides, a difluorobenzene, a member of indazoles, a N-methylpiperazine, a member of oxanes and a secondary amino compound.
Source: ChEBI
| Molecular formula | C31H34F2N6O2 |
|---|---|
| Molecular weight | 560.6 g/mol |
| IUPAC name | N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-2-(oxan-4-ylamino)benzamide |
| InChIKey | HAYYBYPASCDWEQ-UHFFFAOYSA-N |
| SMILES | CN1CCN(CC1)C2=CC(=C(C=C2)C(=O)NC3=NNC4=C3C=C(C=C4)CC5=CC(=CC(=C5)F)F)NC6CCOCC6 |
Computed by PubChem (NCBI)