Entrectinib, 98%

cas: 1108743-60-7 — see every product listed under this CAS number, including other names

Entrectinib, 98% (CAS 1108743-60-7) is a chemical reagent available from Chemat. Available pack sizes: 100MG, 5mg, 25mg, 250mg, 1g. Offered by: Thermo Scientific (Acros), Fluorochem.

brandThermo Scientific (Acros)
catalog number474611000
cas1108743-60-7
size100MG
availability availability
Documents: Safety Data Sheet (MSDS)
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Available pack sizes

brand size price
Thermo Scientific (Acros) 100MG 1069.07 Pln
Fluorochem 5mg 200.99 Pln
Fluorochem 25mg 482.14 Pln
Fluorochem 100mg 1237.08 Pln
Fluorochem 250mg 2143.01 Pln
Fluorochem 1g 4173.55 Pln

properties

delivery time2-3 weeks
categoryChemicals
purity98%
Structural formula: {0} (CAS {1})

Entrectinib is a member of the class of indazoles that is 1H-indazole substituted by [4-(4-methylpiperazin-1-yl)-2-(tetrahydro-2H-pyran-4-ylamino)benzoyl]amino and 3,5-difluorobenzyl groups at positions 3 and 5, respectively. It is a potent inhibitor of TRKA, TRKB, TRKC, ROS1, and ALK (IC50 values of 0.1 to 1.7 nM), and used for the treatment of NTRK, ROS1 and ALK gene fusion-positive solid tumours. It has a role as an antibacterial agent, an antineoplastic agent, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and an apoptosis inducer. It is a secondary carboxamide, a member of benzamides, a difluorobenzene, a member of indazoles, a N-methylpiperazine, a member of oxanes and a secondary amino compound.

Source: ChEBI

Identity
Molecular formulaC31H34F2N6O2
Molecular weight560.6 g/mol
IUPAC nameN-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-2-(oxan-4-ylamino)benzamide
InChIKeyHAYYBYPASCDWEQ-UHFFFAOYSA-N
SMILESCN1CCN(CC1)C2=CC(=C(C=C2)C(=O)NC3=NNC4=C3C=C(C=C4)CC5=CC(=CC(=C5)F)F)NC6CCOCC6

Computed by PubChem (NCBI)

Synonyms: Entrectinib, Rozlytrek, entrectinibum, Entrectinib (RXDX-101), Entrectinib(rxdx-101), Entrectinib [INN], Entrectinib [USAN:INN], Rozlytrek (TN), YMX, Entrectinib, 95%

Also listed as

Entrectinib Chemat Brand CAS 1108743-60-7
Entrectinib/ 99.61% (existing batch purity) TargetMol CAS 1108743-60-7
N-[5-[(3,5-Difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methyl-1-piperazinyl)-2-[(tetrahydro-2H-pyran-4-yl)amino]benzamide, 98%, 98% Chemat CAS 1108743-60-7
Entrectinib, 99.87% MedChemExpress CAS 1108743-60-7
Entrectinib (Standard) MedChemExpress CAS 1108743-60-7