Entrectinib
cas: 1108743-60-7 — see every product listed under this CAS number, including other names
Entrectinib (CAS 1108743-60-7) is a chemical reagent available from Chemat. Available pack sizes: on request, 100mg, 25mg, 5mg, 10mM (in 1ml dmso). Offered by: Chemat Brand, GLPBio.
| brand | Chemat Brand |
|---|---|
| catalog number | ULE131001 |
| cas | 1108743-60-7 |
| size | on request |
| availability | Do potwierdzenia przez Chemat|To be confirmed by Chemat |
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Available pack sizes
| brand | size | price | |
|---|---|---|---|
| Chemat Brand | on request | price on request | |
| GLPBio | 100mg | 2544.13 Pln | |
| GLPBio | 25mg | 1341.24 Pln | |
| GLPBio | 5mg | 657.89 Pln | |
| GLPBio | 10mM (in 1ml dmso) | 849.79 Pln |
properties
| purity | No data |
|---|---|
| category | Chemicals |
| delivery time | To be confirmed by Chemat |
Entrectinib is a member of the class of indazoles that is 1H-indazole substituted by [4-(4-methylpiperazin-1-yl)-2-(tetrahydro-2H-pyran-4-ylamino)benzoyl]amino and 3,5-difluorobenzyl groups at positions 3 and 5, respectively. It is a potent inhibitor of TRKA, TRKB, TRKC, ROS1, and ALK (IC50 values of 0.1 to 1.7 nM), and used for the treatment of NTRK, ROS1 and ALK gene fusion-positive solid tumours. It has a role as an antibacterial agent, an antineoplastic agent, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and an apoptosis inducer. It is a secondary carboxamide, a member of benzamides, a difluorobenzene, a member of indazoles, a N-methylpiperazine, a member of oxanes and a secondary amino compound.
Source: ChEBI
| Molecular formula | C31H34F2N6O2 |
|---|---|
| Molecular weight | 560.6 g/mol |
| IUPAC name | N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-2-(oxan-4-ylamino)benzamide |
| InChIKey | HAYYBYPASCDWEQ-UHFFFAOYSA-N |
| SMILES | CN1CCN(CC1)C2=CC(=C(C=C2)C(=O)NC3=NNC4=C3C=C(C=C4)CC5=CC(=CC(=C5)F)F)NC6CCOCC6 |
Computed by PubChem (NCBI)