GR127935

cas: 148672-13-3 — see every product listed under this CAS number, including other names

GR127935 (CAS 148672-13-3) is a chemical reagent available from Chemat. Available pack sizes: 10mg, 50mg, 25mg, 250mg, 100mg. Offered by: Biosynth.

brandBiosynth
catalog numberYFA67213-10mg
cas148672-13-3
size10mg
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properties

categoryLife Sciences
purityNo data
delivery time3-4 Weeks
Structural formula: {0} (CAS {1})

GR 127935 is a member of the class of benzamides obtained by formal condensation of the carboxy group of 2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carboxylic acid and the anilino group of 4-methoxy-3-(4-methylpiperazin-1-yl)aniline. Potent and selective 5-HT1B/1D receptor antagonist (pKi values are 8.5 for both guinea pig 5-HT1D and rat 5-HT1B receptors). Displays > 100-fold selectivity over 5HT1A, 5-HT2A, 5-HT2C receptors and other receptor types. Centrally active following oral administration. It has a role as a serotonergic antagonist. It is a member of benzamides, a 1,2,4-oxadiazole, a N-alkylpiperazine and a N-arylpiperazine. It is a conjugate base of a GR 127935(1+).

Source: ChEBI

Identity
Molecular formulaC29H31N5O3
Molecular weight497.6 g/mol
IUPAC nameN-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]benzamide
InChIKeyYDBCEBYHYKAFRX-UHFFFAOYSA-N
SMILESCC1=C(C=CC(=C1)C2=NOC(=N2)C)C3=CC=C(C=C3)C(=O)NC4=CC(=C(C=C4)OC)N5CCN(CC5)C

Computed by PubChem (NCBI)

Synonyms: Tocris-1477, Lopac-G-5793, Lopac0_000790, orb1738921, cid_11497466, YDBCEBYHYKAFRX-UHFFFAOYSA-N
Isomers (same molecular formula)
N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-4-[2-methyl-4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]benzamide C29H31N5O3
5-[3-(diethylamino)-6-diethylazaniumylidenexanthen-9-yl]-1-methylbenzotriazole-4-carboxylate C29H31N5O3

Also listed as

GR127935, 99.33% MedChemExpress CAS 148672-13-3
N-(4-Methoxy-3-(4-methylpiperazin-1-yl)phenyl)-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide, 95% Chemat CAS 148672-13-3