Products 148672-13-3
CAS 148672-13-3 appears in our catalog under these names: GR127935, GR127935, 99.33%, N-(4-Methoxy-3-(4-methylpiperazin-1-yl)phenyl)-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide, 95%. Offered by: Biosynth, MedChemExpress, Chemat. Available pack sizes: 10mg, 50mg, 25mg, 250mg, 100mg, 5 mg, 10 mg.
GR 127935 is a member of the class of benzamides obtained by formal condensation of the carboxy group of 2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carboxylic acid and the anilino group of 4-methoxy-3-(4-methylpiperazin-1-yl)aniline. Potent and selective 5-HT1B/1D receptor antagonist (pKi values are 8.5 for both guinea pig 5-HT1D and rat 5-HT1B receptors). Displays > 100-fold selectivity over 5HT1A, 5-HT2A, 5-HT2C receptors and other receptor types. Centrally active following oral administration. It has a role as a serotonergic antagonist. It is a member of benzamides, a 1,2,4-oxadiazole, a N-alkylpiperazine and a N-arylpiperazine. It is a conjugate base of a GR 127935(1+).
Source: ChEBI
| Molecular formula | C29H31N5O3 |
|---|---|
| Molecular weight | 497.6 g/mol |
| IUPAC name | N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]benzamide |
| InChIKey | YDBCEBYHYKAFRX-UHFFFAOYSA-N |
| SMILES | CC1=C(C=CC(=C1)C2=NOC(=N2)C)C3=CC=C(C=C3)C(=O)NC4=CC(=C(C=C4)OC)N5CCN(CC5)C |
Computed by PubChem (NCBI)