JNJ–26854165 (Serdemetan)
cas: 881202-45-5 — see every product listed under this CAS number, including other names
JNJ–26854165 (Serdemetan) (CAS 881202-45-5) is a chemical reagent available from Chemat. Available pack sizes: 5mg, 100mg, 25mg, 10mM (in 1ml dmso). Offered by: GLPBio.
| brand | GLPBio |
|---|---|
| catalog number | GC12117-5 |
| cas | 881202-45-5 |
| size | 5mg |
Available pack sizes
| brand | size | price | |
|---|---|---|---|
| GLPBio | 5mg | 681.29 Pln | |
| GLPBio | 100mg | 2647.10 Pln | |
| GLPBio | 25mg | 1327.20 Pln | |
| GLPBio | 10mM (in 1ml dmso) | 737.45 Pln |
properties
| purity | No data |
|---|---|
| delivery time | To be confirmed by Chemat |
Serdemetan is an orally bioavailable HDM2 antagonist with potential antineoplastic activity. Serdemetan inhibits the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction, the proteasome-mediated enzymatic degradation of p53 is inhibited, which may result in the restoration of p53 signaling and thus the p53-mediated induction of tumor cell apoptosis. HDM2 (human homolog of double minute 2), a zinc finger protein, is a negative regulator of the p53 pathway; often overexpressed in cancer cells, it has been implicated in cancer cell proliferation and survival.
Source: ChEBI
| Molecular formula | C21H20N4 |
|---|---|
| Molecular weight | 328.4 g/mol |
| IUPAC name | 1-N-[2-(1H-indol-3-yl)ethyl]-4-N-pyridin-4-ylbenzene-1,4-diamine |
| InChIKey | CEGSUKYESLWKJP-UHFFFAOYSA-N |
| SMILES | C1=CC=C2C(=C1)C(=CN2)CCNC3=CC=C(C=C3)NC4=CC=NC=C4 |
Computed by PubChem (NCBI)
Synonyms:
Serdemetan, N1-(2-(1H-Indol-3-yl)ethyl)-N4-(pyridin-4-yl)benzene-1,4-diamine, N-(2-(1H-Indol-3-yl)ethyl)-n'-(pyridin-4-yl)benzene-1,4-diamine, serdemetanum, Serdemetan [INN], 1-N-[2-(1H-indol-3-yl)ethyl]-4-N-pyridin-4-ylbenzene-1,4-diamine, n1-[2-(1h-indol-3-yl)ethyl]-n4-4-pyridinyl-1,4-benzenediamine, SERDEMETAN [WHO-DD], orb1223756, orb1305929