Products 881202-45-5

CAS 881202-45-5 appears in our catalog under these names: JNJ–26854165 (Serdemetan), N1-(2-(1H-Indol-3-yl)ethyl)-n4-(pyridin-4-yl)benzene-1,4-diamine, 95%, Serdemetan/ 97.13% (existing batch purity), JNJ 26854165, N1-[2-(1H-Indol-3-yl)ethyl]-N4-4-pyridinyl-1,4-benzenediamine, 98%, 98%. Offered by: GLPBio, Combi-blocks, TargetMol, Biosynth, Chemat. Available pack sizes: 5mg, 100mg, 2mg, 10mg, 25mg, 50mg, 500mg, 10mM (in 1ml dmso).

JNJ–26854165 (Serdemetan)
GLPBio
  • size: 5mg, 100mg, 25mg, 10mM (in 1ml dmso)
  • Variants: 4
from 681.29
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N1-(2-(1H-Indol-3-yl)ethyl)-n4-(pyridin-4-yl)benzene-1,4-diamine, 95%
Combi-blocks
  • size: 100mg
  • Variants: 1
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Serdemetan/ 97.13% (existing batch purity)
TargetMol
  • size: 2mg, 5mg, 10mg, 25mg
  • Variants: 7
from 445.96
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JNJ 26854165
Biosynth
  • size: 10mg, 50mg
  • Variants: 2
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N1-[2-(1H-Indol-3-yl)ethyl]-N4-4-pyridinyl-1,4-benzenediamine, 98%, 98%
Chemat
  • size: 10mg, 50mg, 100mg
  • Variants: 3
from 381.20
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Serdemetan, 99.56%
MedChemExpress
  • size: 50 mg, 100 mg, 5 mg, 10 mg
  • Variants: 5
from 505.45
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Structural formula: {0} (CAS {1})

Serdemetan is an orally bioavailable HDM2 antagonist with potential antineoplastic activity. Serdemetan inhibits the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction, the proteasome-mediated enzymatic degradation of p53 is inhibited, which may result in the restoration of p53 signaling and thus the p53-mediated induction of tumor cell apoptosis. HDM2 (human homolog of double minute 2), a zinc finger protein, is a negative regulator of the p53 pathway; often overexpressed in cancer cells, it has been implicated in cancer cell proliferation and survival.

Source: ChEBI

Identity
Molecular formulaC21H20N4
Molecular weight328.4 g/mol
IUPAC name1-N-[2-(1H-indol-3-yl)ethyl]-4-N-pyridin-4-ylbenzene-1,4-diamine
InChIKeyCEGSUKYESLWKJP-UHFFFAOYSA-N
SMILESC1=CC=C2C(=C1)C(=CN2)CCNC3=CC=C(C=C3)NC4=CC=NC=C4

Computed by PubChem (NCBI)

Synonyms: Serdemetan, N1-(2-(1H-Indol-3-yl)ethyl)-N4-(pyridin-4-yl)benzene-1,4-diamine, N-(2-(1H-Indol-3-yl)ethyl)-n'-(pyridin-4-yl)benzene-1,4-diamine, serdemetanum, Serdemetan [INN], 1-N-[2-(1H-indol-3-yl)ethyl]-4-N-pyridin-4-ylbenzene-1,4-diamine, n1-[2-(1h-indol-3-yl)ethyl]-n4-4-pyridinyl-1,4-benzenediamine, SERDEMETAN [WHO-DD], orb1223756, orb1305929