Serdemetan, 99.56%

cas: 881202-45-5 — see every product listed under this CAS number, including other names

Serdemetan, 99.56% (CAS 881202-45-5) is a chemical reagent available from Chemat. Available pack sizes: 50 mg, 100 mg, 5 mg, 10 mg, 10mM/1mL. Offered by: MedChemExpress.

brand	MedChemExpress
catalog number	HY-12025-50 mg
cas	881202-45-5
size	50 mg
availability	In stock

Available pack sizes

brand	size	price
MedChemExpress	50 mg	2279.46 Pln
MedChemExpress	100 mg	3719.10 Pln
MedChemExpress	5 mg	505.45 Pln
MedChemExpress	10 mg	742.30 Pln
MedChemExpress	10mM/1mL	542.60 Pln

properties

delivery time	1-2 weeks
purity	99.56%

Serdemetan is an orally bioavailable HDM2 antagonist with potential antineoplastic activity. Serdemetan inhibits the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction, the proteasome-mediated enzymatic degradation of p53 is inhibited, which may result in the restoration of p53 signaling and thus the p53-mediated induction of tumor cell apoptosis. HDM2 (human homolog of double minute 2), a zinc finger protein, is a negative regulator of the p53 pathway; often overexpressed in cancer cells, it has been implicated in cancer cell proliferation and survival.

Source: ChEBI

Identity
Molecular formula	C₂₁H₂₀N₄
Molecular weight	328.4 g/mol
IUPAC name	1-N-[2-(1H-indol-3-yl)ethyl]-4-N-pyridin-4-ylbenzene-1,4-diamine
InChIKey	CEGSUKYESLWKJP-UHFFFAOYSA-N
SMILES	C1=CC=C2C(=C1)C(=CN2)CCNC3=CC=C(C=C3)NC4=CC=NC=C4