LCL 161

cas: 1005342-46-0 — see every product listed under this CAS number, including other names

LCL 161 (CAS 1005342-46-0) is a chemical reagent available from Chemat. Available pack sizes: 1g, 2mg, 5mg, 10mg, 25mg. Offered by: TRC, Biosynth.

brandTRC
catalog numberTRC-L270000-1G
cas1005342-46-0
size1g
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Available pack sizes

brand size price
TRC 1g price on request
Biosynth 2mg price on request
Biosynth 5mg price on request
Biosynth 10mg price on request
Biosynth 25mg price on request

properties

purityNo data
delivery timeTo be confirmed by Chemat
Structural formula: {0} (CAS {1})

LCL161 is a small molecule inhibitor of IAPs that has potent antitumour activity in a range of solid tumours. In HCC, response to LCL161 therapy has shown to be mediated by Bcl-2 expression. It has a role as an antineoplastic agent and an apoptosis inducer. It is a member of 1,3-thiazoles, a N-acylpyrrolidine, an aromatic ketone, a member of monofluorobenzenes and a L-alanine derivative.

Source: ChEBI

Identity
Molecular formulaC26H33FN4O3S
Molecular weight500.6 g/mol
IUPAC name(2S)-N-[(1S)-1-cyclohexyl-2-[(2S)-2-[4-(4-fluorobenzoyl)-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxoethyl]-2-(methylamino)propanamide
InChIKeyUFPFGVNKHCLJJO-SSKFGXFMSA-N
SMILESC[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C3=NC(=CS3)C(=O)C4=CC=C(C=C4)F)NC

Computed by PubChem (NCBI)

Synonyms: Nvp-lcl 161, Smac Mimetic LCL161, orb1227172, orb1306530

Also listed as

LCL161 GLPBio CAS 1005342-46-0
LCL161/ 99.72% (existing batch purity) TargetMol CAS 1005342-46-0
LCL161 98% Ambeed CAS 1005342-46-0
(2S)-N-[(1S)-1-Cyclohexyl-2-[(2S)-2-[4-(4-fluorobenzoyl)-2-thiazolyl]-1-pyrrolidinyl]-2-oxoethyl]-2-(methylamino)-propanamide, 98%, 98% Chemat CAS 1005342-46-0
LCL161, 99.91% MedChemExpress CAS 1005342-46-0
Propanamide, N-[(1S)-1-cyclohexyl-2-[(2S)-2-[4-(4-fluorobenzoyl)-2-thiazolyl]-1-pyrrolidinyl]-2-oxoethyl]-2-(methylamino)-, (2S)-, 98% Fluorochem CAS 1005342-46-0