Products 1005342-46-0

CAS 1005342-46-0 appears in our catalog under these names: LCL 161, LCL161, LCL161/ 99.72% (existing batch purity), LCL161 98%, (2S)-N-[(1S)-1-Cyclohexyl-2-[(2S)-2-[4-(4-fluorobenzoyl)-2-thiazolyl]-1-pyrrolidinyl]-2-oxoethyl]-2-(methylamino)-propanamide, 98%, 98%. Offered by: TRC, GLPBio, TargetMol, Biosynth, Ambeed. Available pack sizes: 1g, 10mg, 100mg, 5mg, 10mM (in 1ml dmso), 50mg, 2mg, 25mg.

LCL 161
TRC, Biosynth
  • size: 1g, 2mg, 5mg, 10mg
  • Variants: 5
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LCL161
GLPBio
  • size: 10mg, 100mg, 5mg, 10mM (in 1ml dmso)
  • Variants: 5
from 751.50
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LCL161/ 99.72% (existing batch purity)
TargetMol
  • size: 2mg, 5mg, 10mg, 25mg
  • Variants: 6
from 591.86
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LCL161 98%
Ambeed
  • size: 1g, 1mg, 25mg, 50mg
  • Variants: 6
from 248.00
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(2S)-N-[(1S)-1-Cyclohexyl-2-[(2S)-2-[4-(4-fluorobenzoyl)-2-thiazolyl]-1-pyrrolidinyl]-2-oxoethyl]-2-(methylamino)-propanamide, 98%, 98%
Chemat
  • size: 1g, 1mg, 25mg, 50mg
  • Variants: 6
from 160.40
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LCL161, 99.91%
MedChemExpress
  • size: 50 mg, 10mM/1mL, 5 mg, 10 mg
  • Variants: 5
from 695.86
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Propanamide, N-[(1S)-1-cyclohexyl-2-[(2S)-2-[4-(4-fluorobenzoyl)-2-thiazolyl]-1-pyrrolidinyl]-2-oxoethyl]-2-(methylamino)-, (2S)-, 98%
Fluorochem
  • size: 1mg, 25mg, 50mg, 100mg
  • Variants: 5
from 268.67
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Structural formula: {0} (CAS {1})

LCL161 is a small molecule inhibitor of IAPs that has potent antitumour activity in a range of solid tumours. In HCC, response to LCL161 therapy has shown to be mediated by Bcl-2 expression. It has a role as an antineoplastic agent and an apoptosis inducer. It is a member of 1,3-thiazoles, a N-acylpyrrolidine, an aromatic ketone, a member of monofluorobenzenes and a L-alanine derivative.

Source: ChEBI

Identity
Molecular formulaC26H33FN4O3S
Molecular weight500.6 g/mol
IUPAC name(2S)-N-[(1S)-1-cyclohexyl-2-[(2S)-2-[4-(4-fluorobenzoyl)-1,3-thiazol-2-yl]pyrrolidin-1-yl]-2-oxoethyl]-2-(methylamino)propanamide
InChIKeyUFPFGVNKHCLJJO-SSKFGXFMSA-N
SMILESC[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C3=NC(=CS3)C(=O)C4=CC=C(C=C4)F)NC

Computed by PubChem (NCBI)

Synonyms: Nvp-lcl 161, Smac Mimetic LCL161, orb1227172, orb1306530